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Skip to Search Results- 47Graduate and Postdoctoral Studies (GPS), Faculty of
- 47Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 19Nursing, Faculty of
- 10Nursing, Faculty of/Chronicity
- 7Nursing, Faculty of/Health Systems
- 4Biological Sciences, Department of
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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2011
Barnard, D., Norton, P.G., Cranley, L.A., Estabrooks, C.A., Cummings, G.G.
Background: The current profile of residents living in Canadian nursing homes includes elder persons with complex physical and social needs. High resident acuity can result in increased staff workload and decreased quality of work life. Aims: Safer Care for Older Persons [in residential]...
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Short- and Long-Term Impacts of A Working Memory Intervention for Children with Prenatal Alcohol Exposure
DownloadSpring 2018
This dissertation consists of two studies designed to: (1) determine the neurobehavioural profile reflecting the strengths and limitations of children with Parental Alcohol Exposure (PAE) and (2) evaluate the short- and long-term impacts of a 25-session Cogmed© intervention on improving working...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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Tapeworm (Hymenolepis diminuta) infection in flour beetles (Tribolium confusum): does it cause a trade-off between host fecundity and egg size?
Download2009
Inter- and intra-specific comparisons commonly reveal an inverse relationship between fecundity and offspring size. Many animals also vary egg size in response to environmental conditions. Infection of flour beetles Tribolium confusum Jaquelin Du Val, 1868 with the rat tapeworm Hymenolepis...
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2011
Slaughter, S., Bostrom, A.M., Cummings, G.G., Morgan, D.G., Estabrooks, C.A., Norton, P.G., Squires, J.E.
Background: Defining what constitutes a resident care unit in nursing home research is both a conceptual and practical challenge. The aim of this paper is to provide evidence in support of a definition of care unit in nursing homes by demonstrating: (1) its feasibility for use in data collection,...
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The effectiveness of Return to Duty Intervention: Evaluating an interdisciplinary approach to supporting Canadian Armed Forces members who have physical and non-physical disorders
DownloadSpring 2016
The rate of musculoskeletal and mental health disorders is high in the Canadian Armed Forces, and can preclude service members from being employable and deployable. The aim of this thesis was to analyze the effectiveness of the Return to Duty intervention at decreasing morbidity and assisting...
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The Impact of an Intervention on Social Skills of Young Children with Prenatal Alcohol Exposure
DownloadSpring 2015
FASD is an umbrella term used to describe the continuum of effects that result from prenatal alcohol exposure (PAE) on the developing brain, which causes a multitude of behavioural impairments, including deficits in adaptive behaviours such as social skills. Although there are many interventions...