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Skip to Search Results- 49Older adults
- 27Alzheimer's disease
- 11Cognitive impairment
- 9Aging
- 8Long-term care
- 8Physical activity
- 6Alberta Centre for Active Living
- 6Forbes, D.
- 4Forbes, D.A.
- 4Morgan, D.
- 3Allana, Hunaina
- 3França, Alex
- 41Graduate and Postdoctoral Studies (GPS), Faculty of
- 41Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 19Nursing, Faculty of
- 13Nursing, Faculty of/Chronicity
- 8Alberta Centre for Active Living
- 5ACCES Research Group
- 41Thesis
- 18Article (Published)
- 11Report
- 7Research Material
- 2Conference/Workshop Poster
- 1Learning Object
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Cellular level/distribution of γ-secretase subunit nicastrin and its modulator p23 in the brain
DownloadSpring 2010
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
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Spring 2013
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
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Fall 2013
Background: Ischemic stroke is associated with cognitive impairment, but the acute cognitive sequelae of transient ischemic attack (TIA) and minor stroke is unknown. We hypothesized that transient cognitive impairment can be predicted by diffusion-weighted imaging (DWI) lesion volume. Methods:...
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Fall 2018
Amyotrophic Lateral Sclerosis (ALS) involves the progressive loss of upper and lower motor neurons. Frontotemporal lobar degeneration (FTLD) has been reported in a considerable proportion of patients, manifesting as cognitive and behavioural impairment in at least 25-50%, with 10-15% patients...
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2023-08-31
Low, Gail, Gao, Zhiwei, Gutman, Gloria, Wilson, Donna, França, Alex, Vitorino, Luciano, von Humboldt, Sofia, Allana, Hunaina, Kolskog, Maynard
The COVID-19 pandemic, which greatly affected older people, created a prime opportunity to learn from them about their mentally healthy living strategies—including tips on the most effective strategies for managing anxiety. That was the goal of the RTOERO Foundation-funded project Mentally...
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Data-Driven Approaches to Modeling Heterogeneity and Variability Across Asymptomatic Brain and Cognitive Aging, Mild Cognitive Impairment, and Alzheimer’s disease
DownloadSpring 2024
Objective We apply data-driven approaches to identify predictors of heterogeneous trajectories across normal aging, Mild Cognitive Impairment (MCI), and Alzheimer’s disease (AD). In Study 1, we investigated predictors of left and right hippocampal (HC) volume trajectory classes. In Study 2, we...
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2011
Innes, Anthea, Morgan, Debra, Kosteniuk, Julie
Objectives: The purpose of this review is to critically evaluate the available evidence from the published scientific literature on dementia care and service provision in rural and remote settings from the perspective of formal/paid caregiving, in order to assess the current state of knowledge,...
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Spring 2017
Coronary artery disease (CAD) is the leading cause of mortality in developed countries, followed by depression. Recent literature supports a bidirectional relationship between depression and CAD, which adversely affects the quality of life. Although there is a high prevalence of co-occurring CAD...