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There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
The processing of amyloid precursor protein (APP) by β- and γ-secretases produces amyloid β (Aβ) peptide, the principal component of the neuritic plaques found in Alzheimer’s disease (AD) pathology. The enzyme γ-secretase is a multimeric protein consisting of presenilins-1/2 (PS1/PS2), nicastrin,...
Alzheimer’s disease (AD) is a complex neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ)-related peptides derived from the proteolytic processing of amyloid precursor protein (APP). Research over the last two decades has shown that alterations in the levels...
Objectives: The purpose of this review is to critically evaluate the available evidence from the published scientific literature on dementia care and service provision in rural and remote settings from the perspective of formal/paid caregiving, in order to assess the current state of knowledge,...
Background: The prevalence of dementia, a progressive and incurable condition that affects memory and daily function, is increasing worldwide. The perspective of people with dementia can be captured to better understand which factors impact quality of life for this particular population. Such...
Incidence and prevalence of dementia in linked administrative health data in Saskatchewan, Canada: A retrospective cohort studyDownload
Kosteniuk, Julie G., Crossley, Margaret, Teare, Gary F., Stewart, Norma J., Quail, Jacqueline M., Kirk, Andrew, Bello-Haas, Vanina Dal, O’Connell, Megan E., Forbes, Dorothy A., Morgan, Debra G., Innes, Anthea
Background Determining the epidemiology of dementia among the population as a whole in specific jurisdictions – including the long-term care population–is essential to providing appropriate care. The objectives of this study were to use linked administrative databases in the province of...
The prevalence of dementia in older adults is increasing.Due to cuts in funding for formal support,many families are having to provide care for a loved one with dementia at home.This systematic review gathered and synthesized information on interventions designed to enhance the well-being of...