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Skip to Search Results- 14Cererbral palsy
- 9Angiogenesis
- 3Children
- 3Intrauterine growth restriction
- 2Dysarthria
- 2Endothelial cells
- 1Archibald, Erin D
- 1Bahry, Ashley MA.
- 1Berke, Sheldon S
- 1Chahal, Manik
- 1Condliffe, Elizabeth, G
- 1Corrigan, Jennifer
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Fall 2016
Thrombotic microangiopathy (TMA) is a broad term for a range of diseases that usually manifest with rapid failure of the affected organ. Although different in etiology, these diseases share a common pattern of injury originating in the vascular endothelium. In turn, the injured vasculature...
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Investigating the Role of In Utero Inflammation on Neurodevelopment in the Fetus and Offspring and the Neuroprotective Properties Afforded by Broccoli Sprouts
DownloadFall 2016
Introduction Maternal infection and inflammation leading to a fetal inflammatory response (FIR) is a risk factor for perinatal brain damage. Perinatal brain injury can lead to neurodevelopmental disorders, the sine quo non outcome parameter of which is cerebral palsy (CP). Despite advances in...
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Learning Therapist's Intervention from Demonstration: Application for Robotic Assistance to Children with Cerebral Palsy
DownloadSpring 2018
Physical interaction with the environment and object manipulation play an important role in the development of children's cognitive and perceptual skills. For children who have severe physical impairments, one of the biggest concerns is the loss of opportunities for play. Robots can be used to...
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Manipulation of the Angiogenic Balance by Pharmacological Inhibition of Platelet PKC Signalling
DownloadFall 2012
Blood platelets mediate wound healing by preventing bleeding and by supporting growth of new blood vessels. Blood vessel growth is supported in part by growth factors released from platelet α-granules. Both platelet aggregation and α-granule release are mediated by intracellular signaling...
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Fall 2013
The placenta is an essential transitory fetal organ responsible for the key processes of nutrient, oxygen, and waste transfer between the mother and the fetus throughout gestation. Placental size is, importantly, known to correlate to fetal weight, and the malfunction and malformation of the...
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Fall 2016
This thesis discusses the pathophysiological mechanisms underlying neuromotor impairments in people with spastic cerebral palsy (CP). Ninety percent of people with CP have spastic CP and 60% have bilateral motor impairments. The first two chapters introduce CP and review the mechanisms known to...
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Spring 2016
Cerebral Palsy (CP) constitutes the primary outcome of premature nerve injury. Impairment of oxygen and glucose supply during pregnancy to the fetus can induce neuron damage and death. Mental retardation, seizures, learning disabilities, and other mental diseases can occur as a result of this...
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Novel Insights into the Role of O6-Methylguanine-DNA Methyltransferase in Glioblastoma Angiogenesis, Invasion, and Proliferation
DownloadFall 2012
Glioblastoma multiforme (GBM) is characterized by aberrant angiogenesis, rapid proliferation, and widespread invasion through the brain parenchyma. Thus, the prognosis for these tumors remains extremely poor despite aggressive multimodal treatment including chemotherapy with the alkylating agent...
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Plasma Membrane Organization and Endocytosis of CD36 in Human Microvascular Endothelial Cells
DownloadSpring 2016
The plasma membrane is a dynamic lipid bilayer that surrounds the cell, embedded with different plasma membrane proteins, aiding communication between the inside and outside of the cells. Its functions are achieved through an intricate organization of lipid-lipid, lipid-protein and...