Search
Skip to Search Results- 3Fliegel, Larry
- 1Abdulrahman, Nabeel
- 1Aguilar, Hector N
- 1Albrecht, Elke
- 1Bairwa, Suresh C.
- 1Baral, Pravas Kumar
- 14Graduate and Postdoctoral Studies (GPS), Faculty of
- 14Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 4Agricultural, Food and Nutritional Science, Department of
- 4Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Biochemistry, Department of
- 2Biochemistry, Department of/Journal Articles (Biochemistry)
-
Association of a single nucleotide polymorphism in the bovine leptin gene with feed intake, feed efficiency, growth, feeding behaviour, carcass quality and body composition
Download2004
Hansen, C., Murdoch, B., Guercio, S., Basarab, J. B., Moore, S. S., Meng, Y., Li, C., Nkrumah, J. D.
Leptin is a 16-kDa-hormone product of the obese gene synthesized and expressed predominantly by adipose tissues, which has been shown to play major roles in the regulation of body weight, feed intake, energy balance, fertility, and immune system functions. We report an investigation into the...
-
Cardiomyocyte antihypertrophic effect of adipocyte tissue conditioned medium from rats and its abrogation by obesity is mediated by the leptin to adiponectin ratio
Download2016
Karmazyn, Morris, Proctor, Spencer D., Mangat, Rabban, Gan, Xiaohong T., Bairwa, Suresh C., Rajapurohitam, Venkatesh
White adipocytes are known to function as endocrine organs by secreting a plethora of bioactive adipokines which can regulate cardiac function including the development of hypertrophy. We determined whether adipose tissue conditioned medium (ATCM) generated from the epididymal regions of normal...
-
Characterisation of novel potential phosphorylation sites in the tumour suppressor Merlin in Drosophila
DownloadFall 2014
Neurofibromatosis Type II is an inherited cancer that manifests as various tumours in the nervous system. Mutations and deletions in the tumour suppressor Merlin (moesin, ezrin, radixin-like protein) are linked to the development of the disease. The mechanism by which Merlin suppresses cell...
-
Characterizing the Mesolimbic Dopamine Reward Pathway in a Magel2-null Mouse, a Model of Prader-Willi Syndrome
DownloadFall 2016
Prader-Willi Syndrome (PWS) is a genetic disorder characterized by extreme hyperphagia that can lead to severe obesity. The abnormal motivation to eat in PWS suggests a disruption in the hedonic feeding pathway, which is feeding based on reward as opposed to physiological need. Hedonic feeding is...
-
Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation and anaphase entry
Download2012
Campbell, S.D., Homola, E.M., Fasulo, B., Yu, K.R., Hsieh, T.S., Sullivan, W., Koyama, C.
Defects in DNA replication and chromosome condensation are common phenotypes in cancer cells. A link between replication and condensation has been established, but little is known about the role of checkpoints in monitoring chromosome condensation. We investigate this function by live analysis,...
-
Fall 2014
The vast majority of anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ALCL) tumors carry the genetic translocation t(2;5)(p23;q35), leading to production of the constitutively active fusion tyrosine kinase NPM-ALK. NPM-ALK expression and its potent transformative properties...
-
Fall 2014
An individual’s body weight is tightly regulated by balancing food intake with energy expenditure. This is accomplished in part by secretion of the hormone leptin by adipocytes, an excess of which signals to reduce appetite and increase activity through action in the hypothalamic region of the...
-
IL-6 indirectly modulates the induction of glyceroneogenic enzmes in adipose tissue during exercise
Download2012
Wan, Zhongxiao, Beaudoin, Marie-Soleil, Castellani, Laura, Wright, David C., Ritchie, Ian, Chan, Catherine B.
Background Glyceroneogenesis is an important step in the control of fatty acid re-esterification with PEPCK and PDK4 being identified as key enzymes in this process. We have previously shown that glyceroneogenic enzymes such as PDK4 are rapidly induced in white adipose tissue during exercise....
-
Investigating the roles of phosphorylation in modulating Argonaute 2 activity and localization
DownloadSpring 2017
RNA interference (RNAi) has enabled the study of gene function with unprecedented specificity and reliability. Almost twenty years after the discovery of RNAi, we now know that this process is carried out by a set of evolutionarily conserved proteins. In mammals, these proteins form part of the...