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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Akinwumi, Segun M
- 1Alanis, Ramon
- 1Anderson, Sarah J
- 1Badr, Dina EFA
- 1Boulet, Joel L
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A novel mouse model of acute antibody-mediated transplant rejection shows simultaneous complement activating and anti-inflammatory effects of donor specific IgG antibodies
DownloadFall 2013
We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...
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Fall 2020
Introduction: ABO-incompatible organ transplants (ABOi-Tx) recipients are at high-risk of rapid rejection mediated by ABO antibodies (ABO Abs). To manage and expand ABOi-Tx, it is necessary to understand the mechanism(s) by which natural and induced ABO Abs develop. Prior studies have used...
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An Exploration of the Cost of Liver Transplantation Using the OrganOx Normothermic Machine Perfusion in Comparison to Static Cold Storage in the Canadian Setting
DownloadFall 2021
Liver transplantation is life-saving but costly for the health care system, the patient and their caregivers. Over the last decade there has been a decrease in the available liver grafts leading to an increased use of extended criteria donors and an increase in the waitlist mortality rate. The...
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Fall 2014
Carbohydrate–protein interactions play key roles in a range of biological processes. Noticeable advancements have been made in understanding the features associated with the recognition of pyranosides (six-membered ring sugars) by proteins. In contrast, similar detailed studies about the...
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Behind the Mask: A Narrative Inquiry into Operating Room Nurses' Experiences of Patient Safety
DownloadSpring 2013
The delivery of safe care is an expectation and a central concern of individuals using the healthcare system, particularly for those who find themselves as patients in hospitals. Healthcare researchers' reports and discussions of harm while receiving hospital services speak to the global...
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Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet Transplantation
DownloadFall 2012
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...
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Spring 2012
The purpose of this study was to explore Chinese immigrants’ experiences with human services during the transition to parenthood. The data were generated through three rounds of individual interviews with six Chinese immigrant couples. Latent content analysis was used to identify primary patterns...
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Community Health Centres: Board Governanace and Stakeholder Relations During Service Expansion
DownloadSpring 2013
Despite a significant amount of literature on primary health care, little is understood about primary health care expansion. The current study examines community health centre (CHC) board governance during a period of expansion. Participants (board members) were identified through the publically...
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Culture and the healthy immigrant effect: a multiethnic study of Canadian immigrants' self-perceived health
DownloadSpring 2011
I present a qualitative study investigating the self-perceived health of recently arrived Canadian immigrants. The study develops health promotion’s understanding of culture as a social determinant of health, and conceptually locates it within a broader context of psychosocial factors. The study...
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Spring 2015
Cytomegalovirus (CMV) is the most common opportunistic post-transplant infection. Although important advances have been made in the management and prevention of post-transplant CMV, current strategies for monitoring and prevention still show significant limitations. Such gaps create opportunities...