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Biochemical Characterization of ATP-Binding Cassette Transporter G1 Mediated Cholesterol Efflux
DownloadSpring 2012
ABCG1 mediates cholesterol efflux onto lipidated apolipoprotein A-I and plays an important role in macrophage reverse cholesterol transport, thereby preventing atherosclerosis. However, how ABCG1 mediates cholesterol efflux is unclear. We found that Cys514 located within the third putative...
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Spring 2011
Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...
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Glial Expression of Amyloid Precursor Protein (APP) and its Processing Enzymes in the ANPC Mouse Model
DownloadFall 2021
Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ) peptides derived from the proteolytic processing of amyloid precursor protein (APP). The regions primarily affected in AD brains are the hippocampus and...
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Influence of lipids (arachidonic acid and cholesterol) on calcium signalling in rodent pancreatic beta cells
DownloadFall 2010
Ca2+ is an important mediator of stimulus-secretion coupling in beta cells of the pancreatic islets, which secrete insulin in response to elevation in plasma glucose concentration. I studied the actions of two lipids, arachidonic acid (AA) and cholesterol, on enzymatically-dissociated single...
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Fall 2017
The nucleus is a hallmark of eukaryotic cells. It segregates the genetic material from the cytoplasm. The nucleus is encapsulated by the nuclear envelope which is perforated with nuclear pore complexes (NPCs), macromolecular structures formed by proteins termed nucleoporins (Nups). NPCs and...
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Fall 2013
ATP-binding cassette transporter G1 (ABCG1) mediates sterol efflux onto lipidated lipoproteins and plays an important role in macrophage cholesterol homeostasis. In this project, we investigated how ABCG1 works as a functional transporter to mediate sterol translocation. First, we found a...
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Tiered Behaviour Architecture for Virtual Characters using Cyclic Scheduling and Behaviour Capture
DownloadSpring 2015
A story-based video game contains many characters. A few are controlled by the player and the majority are virtual characters, controlled by artificial intelligence. In recent years, video game artificial intelligence has developed slower than other aspects of video games, such as graphics,...
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Spring 2023
Many competitive online video games release new characters on a regular basis. Designing these characters requires significant effort on several aspects including art, story, music, and game balance. Thus automating the design of these aspects offers value in saving human effort. This thesis...