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Silencing immunoglobulin gene enhancers as a potential treatment strategy for multiple myeloma
DownloadFall 2009
Multiple myeloma is a bone marrow malignancy characterized by the presence of monoclonal plasma cells. In 50-75% of myeloma patients, chromosome translocations at the IgH locus are observed, which result in overexpression of oncogenes from the translocated chromosome due to linkage with the IgH...
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