This week, we need to do work to address a component of our application that requires immediate attention. As a result, you may experience ERA to be intermittently available. We apologize for any inconvenience this may cause, and thank you for your patience as we attend to the care and feeding of ERA!
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- 2Howell, P. Lynne
- 2Kitova, Elena N.
- 2Klassen, John S.
- 2Robinson, Howard
- 1Baker, Perrin
- 1Clarke, Anthony J.
Pseudomonas aeruginosa is an opportunistic pathogen that forms chronic biofilm infections in the lungs of cystic fibrosis patients. A major component of the biofilm during these infections is the exopolysaccharide alginate, which is synthesized at the inner membrane as a homopolymer of 1–4-linked...
P. aeruginosa SGNH hydrolase-like proteins AlgJ and AlgX have similar topology but separate and distinct roles in alginate acetylationDownload
Howell, P. Lynne, Klassen, John S., Robinson, Howard, Kitova, Elena N., Dawson, Karen, Clarke, Anthony J., Little, Dustin J., Walvoort, Marthe T., Weadge, Joel T., Codee, Jeroen D. C., Baker, Perrin, Whitney, John C., Ohman, Dennis E., Ricer, Tyler, Moynihan, Patrick J.
The O-acetylation of polysaccharides is a common modification used by pathogenic organisms to protect against external forces. Pseudomonas aeruginosa secretes the anionic, O-acetylated exopolysaccharide alginate during chronic infection in the lungs of cystic fibrosis patients to form the major...