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Recombinant expression of the cardiac troponin I fragment, cTnI[135-209], that controls cardiac contraction
Download2015-05-14
Jonathan S. Pan, Somaya Zahran, Peter M Hwang
Intrinsically disordered regions (IDRs) are protein segments that lack a fixed three-dimensional structure under physiologic conditions, they are susceptible to post-translational modifications such as proteolysis. However, they are highly important in cellular signal transduction and the...
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Troponin degradation products: more specific marker for myocardial infarction
2017-04-01
Somaya Zahran, Vivian Figueiredo, Michelle Graham, Peter M Hwang, George Cembrowski, Richard Schulz
Introduction Myocardial infarction (MI) is the death of cardiac muscle in the setting of severe ischemia (lack of oxygen and nutrient supply). Assay of serum troponin I (TnI) is the biochemical gold standard for detecting MI. With the development of high sensitivity assays, TnI is being detected...