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Author / Creator / Contributor

1Miyyapuram, Venugopal

Subject / Keyword

1Bacillus subtilis--Genetics
1Cyclic peptides--Synthesis
1Cysteine proteinases--Inhibitors--Evaluation
1Cysteine proteinases--Inhibitors--Synthesis
1Peptide antibiotics--Synthesis
1SARS (Disease)--Chemotherapy

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1Graduate and Postdoctoral Studies (GPS), Faculty of
1Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations

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1English

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1Thesis

Departments

1Department of Chemistry

Supervisors

1Dr. John C. Vederas (Department of Chemistry)

Synthesis and investigation of viral cysteine protease inhibitors and biosynthetic studies on subtilosin A
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Fall 2009

Miyyapuram, Venugopal

ABSTRACT This thesis discusses the synthesis and evaluation of cysteine protease inhibitors, the asymmetric reduction of pseudoxazolones, and the study of the mechanism of subtilosin A biosynthesis. Five classes of compounds, including pyridinylamines and ethers, have been designed with the aim...

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Synthesis and investigation of viral cysteine protease inhibitors and biosynthetic studies on subtilosin A