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Skip to Search Results- 2Hwang, Peter M.
- 2Li, Monica X.
- 1Cai, Fangze
- 1Gelozia, Shorena
- 1Lindert, Steffen
- 1Pineda-Sanbria, Sandra E.
- 2Calcium sensitizer
- 1Cardiac troponin activator
- 1Dilated cardiomyopathy
- 1Drug development
- 1Heart failure
- 1Hypertrophic cardiomyopathy
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Structure and Function of Cardiac Troponin C (TNNC1): Implications for Heart Failure, Cardiomyopathies, and Troponin Modulating Drugs
Download2015-01-01
Li, Monica X., Hwang, Peter M.
In striated muscle, the protein troponin complex turns contraction on and off in a calcium-dependent manner. The calcium-sensing component of the complex is troponin C, which is expressed from the TNNC1 gene in both cardiac muscle and slow-twitch skeletal muscle (identical transcript in both...
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2016-01-01
Cai, Fangze, Li, Monica X., Pineda-Sanbria, Sandra E., Gelozia, Shorena, Lindert, Steffen, West, Frederick, Sykes, Brian D., Hwang, Peter M.
In cardiac and skeletal muscle, the troponin complex turns muscle contraction on and off in a calcium-dependent manner. Many small molecules are known to bind to the troponin complex to modulate its calcium binding affinity, and this may be useful in a broad range of conditions in which striated...