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Skip to Search Results- 10Hegele, Robert A.
- 10Young, T. Kue
- 8Wang, Jian
- 6Ban, Matthew R.
- 6Connelly, Philip W.
- 5Bjerregaard, Peter
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1999-08-04
Hegele, Robert A., Anderson, Carol, Young, T. Kue, Connelly, Philip W.
"The GNB3 825T allele encodes a product that has enhanced activation of heterotrimeric G proteins in vitro and could play a role in adipogenesis. We therefore evaluated the possibility that the GNB3 825T allele was associated with obesity in a sample of 213 healthy Canadian Inuit. We found that...
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Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans
Download2003-05-13
Wen, Xiao-Yan, Hegele, Robert A., Wang, Jian, Wang, Ding Yan, Cheung, Joseph, Wilson, Michael, Yahyapour, Maryam, Bai, Yahong, Zhuang, Lihua, Skaug, Jennifer, Young, T. Kue, Connelly, Philip W., Koop, Ben F., Tsui, Lap-Chee, Stewart, A. Keith
"Triglyceride (TG) metabolism is crucial for whole body and local energy homeostasis and accumulating evidence suggests an independent association between plasma TG concentration and increased atherosclerosis risk. We previously generated a mouse insertional mutation lpd (lipid defect) whose...
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Promoter Polymorphism in PCK1 (Phosphoenolpyruvate Carboxykinase Gene) Associated with Type 2 Diabetes Mellitus
Download2004-02-01
Cao, Henian, van der Veer, Eric, Ban, Matthew R., Hanley, Anthony J.G., Zinman, Bernard, Harris, S. B., Young, T. Kue, Pickering, J. Geoffrey, Hegele, Robert A.
"We sequenced the promoter and coding regions of PCK1 encoding cytosolic phosphoenolpyruvate carboxykinase from genomic DNA of subjects with type 2 diabetes mellitus (DM). We found nine single nucleotide polymorphisms (SNPs) that were present with varying allele frequencies and pairwise linkage...
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Rare ATGL haplotypes are associated with increased plasma triglyceride concentrations in the Greenland Inuit
Download2012-03-18
Johansen, Christopher T., Gallinger, Zane R., Wang, Jian, Ban, Matthew R., Young, T. Kue, Bjerregaard, Peter, Hegele, Robert A.
"Objectives: To genotype common genetic variants found in the adipose triglyceride lipase (ATGL) gene and test them for association with cardiovascular disease risk factors in the Greenland Inuit. Study design: Candidate gene association study of discrete and quantitative traits related to...