Search
Skip to Search Results- 1Drummond, Danna L
- 1Erickson, Timothy
- 1Holly, Vanessa L
- 1Lukowski, Chris
- 1Mackowetzky, Kacey
- 1Selland, Lyndsay
-
Fall 2015
Vertebrate eye development is a dynamic process that couples morphogenesis, migration of extraocular periocular mesenchyme (POM) cells to the eye, and retinal patterning along the nasotemporal and dorsoventral (DV) axes. Aberrant patterning during ocular development often results in defects...
-
Spring 2020
Ocular coloboma is a congenital disorder that presents as an ocular malformation in the inferior aspect of the eye and may result in blindness. Recently, our lab characterized a novel disorder, superior coloboma, which presents as a coloboma affecting the superior portion of the eye. We...
-
Investigation of the Genetic Etiology of Superior Coloboma and the Formation and Closure of Superior Ocular Sulcus
DownloadSpring 2022
Congenital ocular coloboma is a rare genetic disorder that is typically observed as a cleft in the inferior aspect of the eye due to failed choroid fissure closure during embryogenesis. Together with microphthalmia (small eyes) and anophthalmia (absence of eyes), it represents 3-11% of childhood...
-
Fall 2012
Sensory systems are complex structures that receive stimuli from the surrounding environment and convert them into interpretable information. In the visual system, light hitting the eye is transmitted to the brain in a way that preserves the spatial conformation of the pictures we see. Retinal...
-
Spring 2010
Development of the vertebrate central nervous system is a complex process that relies on the accurate spatiotemporal distribution of signaling centers during embryogenesis. These signals provide cells with positional information, which is integrated via transcription factors and gene regulatory...
-
Retinoic Acid Signaling in Late Vestibular Development of the Inner Ear and Techniques for Visualizing the Zebrafish Inner Ear
DownloadFall 2021
The vertebrate inner ear is a labyrinthine sensory organ responsible for perceiving sound and body motion. A wide range of disorders of the inner ear can arise from congenital disorders, necessitating the identification of molecular components or pathways involved in its development to better...
-
Roles for Transcription Factors and Signaling Pathways in Hindbrain Segmentation and Ventricle Morphogenesis
DownloadFall 2018
During development, expression and localization of transcription factors and transcriptional co-regulators must be tightly controlled, and in turn they are required to regulate cellular identity and cellular processes. Often this involves complex interactions with signaling pathways. We are...
-
The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterning
DownloadFall 2010
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...
-
Zic transcription factors regulate retinoic acid metabolism during zebrafish neural development
DownloadSpring 2012
Retinoic acid (RA) has a crucial role in embryonic nervous system development - controlling anterior-posterior patterning, neural differentiation, and cell proliferation. During zebrafish embryogenesis, levels of RA are tightly regulated by the combinatorial action of synthesis and degradation...