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Skip to Search Results- 1Braithwaite, Shannon Lynn
- 1Ding, Ning
- 1Hagen, Mariel O
- 1Katzenback, Barbara A
- 1Kovacevic, Nikolina
- 1Price, Luke M.
- 3Goldfish
- 3Prions
- 2Macrophages
- 2Protein misfolding cyclic amplification
- 1Acute phase proteins
- 1Acute phase response
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Analysis of goldfish innate immunity following exposure to oil sands process affected water
DownloadFall 2013
The acute and sub chronic effects of oil sands process affected water (OSPW) and its toxic component, naphthenic acids (NAs) were examined. I exposed goldfish for one (acute), or 12 (sub chronic) weeks and examined immune gene expression, macrophage function, the ability of exposed fish to...
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Analysis of the acute phase response in goldfish (Carassius auratus L.) infected with Trypanosoma carassii
DownloadSpring 2016
The innate immune response is a fundamental defense mechanism in bony fishes and a crucial component of innate immunity is the acute phase response (APR). The APR is a systemic and/or local response to any injury, infection, or trauma and is characterized by a change in the blood composition of...
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Characterizing patterns of tissue tropism and environmental reservoirs of PrPCWD in infected cervids
DownloadFall 2013
Chronic wasting disease (CWD) is a fatal prion disease affecting cervids. Believed to be transmitted horizontally, the factors affecting CWD contagion are unknown, but bodily fluids or excretions have been implicated as possible routes of transmission. Protein misfolding cyclic amplification...
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Fall 2013
Misfolded prions (PrPSc) are well known for their resistance to conventional decontamination processes. The potential risk of contamination of the water environment, as a result of the disposal of specified risk materials (SRM), has raised public concerns. Ozone is commonly utilized in the water...
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Optimization, adaptation and application of protein misfolding cyclic amplification to detection of prions in blood plasma
DownloadFall 2010
The PMCA assay was optimized for adaptation to low level detection of PrPSc in hamster plasma. Evaluation of numerous key variables of the PMCA assay led to an optimized protocol capable of ~3 log10 amplification after 32 cycles (two 16 hour rounds). When commercially purchased normal hamster...
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Spring 2012
Development of progenitor cells into myeloid cells (i.e. macrophages and neutrophils) is critical to the survival of metazoans for maintenance of homeostasis and defense against pathogens. While much is known about myeloid cell development in mammals, less is known about this process in fish. The...
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The biology and characterization of NOD-like receptors in goldfish (Carassius auratus L.) macrophages exposed to bacterial pathogens
DownloadSpring 2017
The recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) is important for the initiation of the host defense against pathogens. NOD-like receptors (NLRs) are a family of PRRs that primarily detect the cytosolic PAMPs of the pathogens. The NLRs have...