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Spring 2016
Tamoxifen is the accepted therapy for patients with estrogen receptor α (ERα)−positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...
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Understanding the alteration of the Tagish Lake meteorite through mineralogy, geochemistry and oxygen isotopes
DownloadFall 2013
Our understanding of the origin and formation of the various components of meteorites, and ultimately understanding the formation of the early Solar System, comes from our knowledge of the asteroidal alteration processes and modifications that such processes induce on these components. The...
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Understanding the Changes in Positive and Negative Sentiments in the Discourse of the COVID-19 Pandemic in Alberta
DownloadSpring 2024
The severe acute respiratory syndrome caused by the SARS coronavirus was declared a pandemic in March 2020 by the World Health Organisation. Alberta as other provinces and countries had to face the challenge of fighting this syndrome that caused what is commonly known as the COVID-19 pandemic....
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Understanding the Chemistry of Conversion of Model Compounds and Biomass by Hydrous Pyrolysis Based on Spectroscopic Data Using Data Fusion, Data Mining, and Chemometrics
DownloadFall 2019
Encoding the presence of multispecies in a complex system, difficulty in characterizing the physical constituents of the products with analytical instruments along with developing the causality or modeling between these groups are some major challenges in a complex system such as biomass...
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Understanding the Context of Pharmacy Practice Change: Gaining insight into the professional culture of pharmacy and pharmacists’ personality
DownloadFall 2014
Background: Pharmacists around the world are being asked to adopt, and integrate, an increasing number of clinical services into their practices. Evidence for the efficacy of pharmacists’ interventions in patient care also continues to grow. Traditional approaches to understanding practice change...
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Understanding the Deposition and Molecular Interaction Mechanisms of Substrate-supported Functional Coatings
DownloadFall 2017
Functional coatings have been extensively exploited for creating surfaces with desired functionalities in numerous engineering applications, which have received increasing attention over the past few decades. The objectives of this thesis research were to develop stable, hydrophobicity-tunable...
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Understanding the Effect of Non-starch Grain Components on the Amylolysis of Starch in Whole Grains
DownloadSpring 2016
Bioethanol industry is fast growing as it is a clean substitute of fossil-fuel. Starch is a clean, cheap & non-toxic source for bioethanol production. Efficient conversion of starch to fermentable sugars is important. The objective of this research was to investigate the effect of non-starch...
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Spring 2022
Estimating costs for construction projects is a complex and often uncertain process. Given the inherent uncertainty of estimating and the unique risk profile of each construction project, many owners use cost uncertainty analysis to understand a project’s range of potential costs. Since results...
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Understanding the Effects of Hydrogen, Hydrostatic testing and Mill- scale on SCC of Pipelines in Near-Neutral pH Environment
DownloadFall 2016
Near-neutral pH stress corrosion cracks (NNpH SCC) are developed under coating disbondments on the external surface of pipelines where the surface of pipeline is exposed to the soil solution. NNpH SCC initiation and early stage of growth is mainly governed by the dissolution process of steel....
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Understanding the effects of therapeutic HER2 antibodies trastuzumab and pertuzumab on HER2-mediated cell signaling
DownloadFall 2020
The ErbB family of receptor tyrosine kinases, also called the HER receptors, consists of four members including epithelial growth factor receptor (EGFR), erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4). HER2 overexpression has been reported in 20-30% of breast cancer cells and is responsible for...