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Spring 2019
IntroductionAs the cornerstone of high-quality health care, patient safety was first brought to light with the Institute of Medicine’s (IOM) To Err is Human seminal report in 1999 that outlined the gulf between what is desired to what really exists. This report launched intense research efforts...
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Measurement properties of primary outcome measures in pediatric RCTs: inadequate reporting, insufficient validation, or both?
DownloadFall 2013
Randomized controlled trials (RCTs) are the gold standard for high quality evidence generation pertaining to treatment effectiveness. RCT results are used in knowledge synthesis and evidence-based practice. The validity of RCT results is dependent upon the validity of the primary outcome...
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Fall 2014
Background: N-of-1 trials are prospectively planned, multiple crossover evaluations, conducted in individual patients. Evidence shows that a range of designs and statistical methods have been applied to N-of-1 trials. This thesis helps to provide a comprehensive understanding about the...
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Spring 2010
INTRODUCTION Antioxidant micronutrients may help alleviate oxidative stress in cystic fibrosis (CF) lung disease. To determine treatment effect, systematic reviews (SR) synthesize available evidence. Cochrane SRs are known for being methodologically rigourous, however, may have...
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Patient-reported outcome measures for adverse events: A systematic review and COSMIN evaluation study
DownloadFall 2017
ABSTRACT Background: Health care requires constant improvement. Harms in health care are becoming a priority, as is incorporating the patient’s voice in both clinical research and clinical care. Patients have been found to provide a more subjective, detailed perspective of their treatment...
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The Detection and Causality Assessment of Adverse Events Related to Natural Health Product Use in Community Pharmacies through the Implementation of Active Surveillance.
DownloadSpring 2013
Background: Natural health products (NHP) are widely used by the public. Since NHPs are pharmacologically active products, their ability to cause adverse reactions (AR) is present and well-documented. Currently employed passive surveillance systems are not well-equipped to detect NHP adverse...