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Development of Cu-Catalyzed Decarboxylative Heteroarylation and Rh-Catalyzed Carbene Olefination
DownloadFall 2017
Transition metal-catalyzed cross-coupling reactions are widely used transformations to generate useful chemicals. The development of new variants for transition metal-catalyzed cross-coupling reactions provides more efficient methods for the construction of functionalized molecules. This thesis...
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Development of New Late-Stage Labeling Methods with Labeled Carbon for Stabilized Carboxylic Acids and α-Amino Acids
DownloadFall 2023
Isotope labeling of small molecules is a crucial tool for drug discovery and understanding biochemical processes. Expanding the toolbox of a radiochemist with methods that allow late-stage labeling is therefore important. Of the methods that have been developed, the use of isotopically labeled...
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Development of Rh-Catalyzed Chemoselective Z-Olefin Synthesis and Ir- and Pd-Catalyzed Decarboxylative Enantioselective Benzylation
DownloadSpring 2019
Transition metal-catalyzed bond-forming reactions are powerful strategies in modern organic synthesis, which enable various functional group transformations and cross-coupling processes in a highly chemo-, regio- and enantioselective manner. Selectivity can be achieved through the appropriate...
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Development of Rhodium Catalyzed Formic Acid Mediated Z-Selective Alkene Synthesis from Electron Deficient Dienes
DownloadFall 2020
Z-Alkenes are important functional moieties in biological molecules and serve as versatile units for chemical transformations in synthetic chemistry. Synthetic strategies to readily generate these less thermodynamically stable alkenes with high regio-, chemo- and stereocontrol remain challenging,...
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Fall 2022
Cooze, Christopher Joseph Craig
The metal-catalyzed addition of nucleophiles to electron-deficient alkenes represents one of the most useful tools for the construction of carbon-carbon and carbon-heteroatom bonds. Of the methods that have been developed, the Rh-catalyzed conjugate addition of aryl and alkenyl boronic acids to...
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Fall 2018
Transition-metal catalyzed cross-coupling reactions are a broad set of tools that enable the generation of molecular complexity by coupling together molecular pieces. This is done by the use of activating groups on the molecular pieces and a metal-based catalyst. These methods are widely used in...