Development of Rhodium Catalyzed Formic Acid Mediated Z-Selective Alkene Synthesis from Electron Deficient Dienes

• Author / Creator

  Dada, Raphael O.

• Z-Alkenes are important functional moieties in biological molecules and serve as versatile units for chemical transformations in synthetic chemistry. Synthetic strategies to readily generate these less thermodynamically stable alkenes with high regio-, chemo- and stereocontrol remain challenging, as these methods require stoichiometric main-group activators or are poorly tolerant of reactive functional groups. Selective hydride addition to electron deficient dienes and their use as pronucleophiles in reductive coupling processes can serve as an alternative to the already existing strategies. This thesis describes the development of a new chemo-, regio-, and stereoselective synthesis of Z-alkenes from electron deficient dienes mediated by formic acid using Rh-catalysis.

• Subjects / Keywords

  • formic acid
  • Reduction
  • Rhodium
  • Alkene
  • Z-Homoallylic amine
  • electron deficient diene
  • Z-Homoallylic alcohol
  • Reductive coupling
  • Z-Selective

• Graduation date

  Fall 2020

• Type of Item

  Thesis

• Degree

  Doctor of Philosophy

• DOI

  https://doi.org/10.7939/r3-4b4q-6009

• License

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