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Skip to Search Results- 1Abdul Rahman, Siti Aishah
- 1Acton, Leah T
- 1Aghamohammadi Sereshki, Arash
- 1Ainsley, Emily N.
- 1Bandet, Mischa V.
- 1Batty, Nicholas J.
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Spring 2024
Recovery after stroke depends on the extent of neuronal regeneration and myelination of existing and newly differentiated neurons. Regeneration process is governed by various factors released from glial cells. During an injury, glial cells activate and form a glial scar surrounding the lesion...
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Fall 2018
Sex traditionally has been an understudied variable in the chronic pain literature. However, more recent research has begun to explore the role of sex in the etiology of chronic pain. The present thesis adds to the current literature by expanding on research demonstrating the significant effect...
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Going Through the Motions: Evaluating the Impact of Task, Device and Platform on Mouse-Tracking Derived Measures of Decision Difficulty
DownloadFall 2021
As decisions require actions to have an effect on the world (Cisek & Kalaska, 2010), measures derived from movements can be used to provide a powerful index of decision-making processes (e.g., Gallivan & Chapman, 2014). Measures of trajectory curvature (interpreted as a competitive pull from the...
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Hippocampal Diffusion Tensor Imaging in Parkinson's Disease and Associations with Non- Motor Symptoms
DownloadSpring 2023
Parkinson’s disease (PD) is the second most common neurodegenerative disorder and causes not only well-characterised motor symptoms, but also a host of non-motor symptoms that greatly impact quality of life. PD exists within a larger spectrum of disorders caused by the accumulation of Lewy bodies...
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Imaging the hemodynamics of pial collaterals and evaluating collateral therapeutics in rodent models of acute ischemic stroke
DownloadFall 2019
Ischemic stroke is caused by blockage of a primary blood vessel supplying brain tissue. Cerebral collaterals are auxiliary vascular pathways in the cerebral circulation that can provide residual blood flow to partially maintain perfusion in ischemic tissue when primary vascular routes are...
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Integrating Characteristics of Executive Functions in Non-Demented Aging: Structure, Trajectories, Classification, and Biomarker Predictors
DownloadSpring 2019
In aging, executive function (EF) performance (level) and change (trajectory) are linked to multiple interacting risk factors. Structurally, EFs have previously been represented as either a unitary (e.g., unidimensional) or diverse (e.g., multidimensional) set of abilities that change across the...
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Intermittent Electrical Stimulation as a Treatment Approach for Deep Tissue Pressure Injury after a Spinal Cord Injury
DownloadFall 2018
The goal of this study was to investigate the effects and mechanisms of action of an intermittent electrical stimulation (IES) paradigm on the healing of deep-seated muscle injury. Electrical stimulation has been extensively studied for the treatment of open wounds, often with amplitudes lower...
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Investigating Human Brain Function and Human Brain Organization Using Functional Magnetic Resonance Imaging at 4.7 T
DownloadFall 2020
Understanding the brain-cognition association has been a major goal of neuroscientists for more than 50 years. The discovery of functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) contrast by Ogawa and colleagues (1990, 1992) has fundamentally transformed the field of...
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Investigating Mechanisms Responsible for the Pro-Regenerative Effects of Conditioning Electrical Stimulation
DownloadFall 2022
Though capable of regeneration, repair surgeries following peripheral nerve injury are often incomplete or entirely unsuccessful. The slow rate of regeneration (1-3mm/day) of a proximal injury requires up to two years to reach the distal target, whereas significant muscle atrophy occurs after...