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Development and partial validation of a bioanalytical assay for the detection of a novel bone-targeting parathyroid hormone conjugate using metal-free LC-MS/MS
DownloadFall 2020
In an effort to address shortcomings with current drug treatments for osteoporosis (OP) and improve the efficacy of human parathyroid hormone (hPTH(1-34)), we have employed a bisphosphonate-conjugation strategy by tethering hPTH(1-34) to a non-nitrogenated bisphosphonate (BP) moiety (BP-PTH) in...
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Fall 2018
Osteoporosis is one of the prevalent disorders that exist in both humans and chickens. The bone disorder is characterized by depletion of bone mineral content, leading to fragile bones and increases susceptibility to fractures. During the egg laying cycle, cage layers are more prone to fragile...
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Single Chain Fraction Variable Binding Molecules as Bone-Targeting Therapeutics and Diagnostics
DownloadFall 2011
Osteoporosis is a disease characterized by lowering of bone mass and subsequent bone fracture. Although successful antiresorptive treatment options are commercially available, they have disadvantages such as poor bioavailability and significant side effects. Using phage display, an in vitro high...
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Fall 2009
Osteoporosis is a skeletal disorder that affects millions of people worldwide, and is characterized by the accelerated loss of bone mass. Current anti-resorptive drug approaches such as bisphosphonates and salmon calcitonin exhibit severe side effects and very low bioavailability, respectively....