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Skip to Search Results- 2Sigalet, David L.
- 2Yamoah, Ebenezer Nketia.
- 1Aboelnazar, Nader Saber
- 1Abualhassan, Nasser
- 1Adegoke, Adeolu
- 1Aggarwal, Saloni
- 7Mesenchymal stem cells
- 7Scars
- 6Diabetes
- 6Islet transplantation
- 5Cerebrovascular spasm--Animal models
- 5Fibroblasts
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Fall 2009
Islet transplantation has the potential to be an effective treatment for patients with type 1 diabetes. However, a shortage of human donor islets and the need for continuous immunosuppressive therapy currently limit this therapy to patients with brittle type 1 diabetes. Neonatal pigs may...
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Spring 2013
Type 1 diabetes mellitus (T1DM) is a chronic disorder of glucose metabolism due to autoimmune destruction of insulin producing β-cells. Although insulin therapy is the standard treatment for T1DM, islet transplantation, which has emerged as an alternative to insulin injection, offers a more...
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Fall 2013
The hepatitis C virus leads to chronic infection in the majority of infected individuals; however, in a minority of patients, acute infection is followed by viral clearance. The immune correlates of viral clearance are not yet clear, but have been extensively investigated, suggesting the role of...
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Molecular Prognostication of Oral Cavity Squamous Cell Carcinoma by Tissue Microarray Analysis
DownloadSpring 2018
AimsOral cavity squamous cell carcinoma (OCSCC) is a molecularly heterogeneous disease, which is thought to account for differences in treatment response between patients who have otherwise similar characteristics. Cancer biomarkers provide a means of molecular classification, which can be of...
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Fall 2009
MUC1, a protein of epithelial and carcinoma cells, has recently been shown on activated T cells where it inhibits CD3-stimulated proliferation. Two immunoregulatory domains similar to ITAM and ITIMs are present on its cytoplasmic tail, suggesting that MUC1 can act as both a costimulatory and...
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Spring 2019
Lung transplantation is a life-saving therapy for patients suffering from end-stage lung disease; however, there exists a discrepancy between suitable donor grafts and utilization rates. At most, only 40% of offered donor lungs are utilized for transplantation. The majority are deemed...
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Fall 2019
Background Islet transplantation is an attractive alternative treatment for type 1 diabetes mellitus (T1DM). However, further application of islet transplantation in the clinic is limited by the shortage of human organ donors and the immune-mediated rejection. Neonatal pig islets (NPI) are being...
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Neonatal Porcine Islet Xenotransplantation: Non-invasive in vivo imaging and basic islet biology
DownloadFall 2022
Islet transplantation has been proven as a successful clinical therapy for diabetes; however, its widespread use is limited by multiple factors including a shortage of human donors, the need for long term immunosuppression and difficulty with graft monitoring post transplantation. Pig islet...