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Skip to Search Results- 2Sigalet, David L.
- 2Yamoah, Ebenezer Nketia.
- 1Aboelnazar, Nader Saber
- 1Abualhassan, Nasser
- 1Adegoke, Adeolu
- 1Aggarwal, Saloni
- 7Mesenchymal stem cells
- 7Scars
- 6Diabetes
- 6Islet transplantation
- 5Cerebrovascular spasm--Animal models
- 5Fibroblasts
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Characterization of Human Pancreatic Beta-cell Progenitors as a Means to Alleviate the Shortage of Donor Tissue for Islet Transplantation
DownloadFall 2012
The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...
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Characterization of hypertrophic scar formation in nude and knockout mice deficient in T, B and natural killer cells
DownloadSpring 2012
Introduction: Hypertrophic scar (HSc) is a fibroproliferative disorder lacking a relevant animal model. Our objective is to characterize proliferative scars in human xenografts generated after grafting human skin onto mice deficient in T, B and natural killer cells. Methods: Nude, T-cell receptor...
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Characterizing the Efficacy of Ice Recrystallization Inhibitors as a Novel Cryoprotectant for Lung Cryopreservation
DownloadFall 2020
Although lung transplant remains the only option for patients suffering from end-stage lung disease, donor lung supply is currently insufficient to meet demand. While many lungs become available for transplant, most are discarded due to failure to meet physiologic or compatibility criteria. Many...
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Clinical and Translational Studies Advancing Clinical Implementation of Stem Cell-Derived Islet Transplantation
DownloadSpring 2024
Twenty-years ago Shapiro et al. revolutionized islet transplantation (ITx), realizing the potential for a cell-based diabetes treatment. Despite improvements, ITx remains restricted by organ donor limitations and immunosuppression. Stem cell (SC)-derived ITx (SC Tx) could eliminate these...
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Fall 2017
Mesenchymal stem cells (MSCs) have immuno-regulatory, anti-inflammatory, and pro-angiogenic properties through the secretion of a myriad of trophic factors, and have been shown to have a beneficial effect on graft function. In this thesis we investigated whether MSCs’ have an effect on neonatal...