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Fall 2021

Amusan, Precious

Despite the wide-spread availability of modern, combination antiretroviral therapy (cART), neurocognitive impairment persists among some people living with HIV (PWH). Among the multiple, interrelated HIV-associated, comorbid, and demographic factors related to neurocognitive problems in HIV today...

Spring 2020

Bahram Victor Foroutanpay

Human β-amyloid1-42 (hAβ1-42) peptides are known to self-aggregate into oligomers that contribute to the degeneration of neurons and development of Alzheimer's disease (AD) pathology. Unlike humans, rodents do not develop AD, possibly due to differences in three amino acids (R5G, Y10F and H13R)...

Spring 2020

Mohammad Murshedul Alam

Alzheimer’s disease (AD), the most common type of senile dementia, is characterized by the presence of β-amyloid (Aβ)-containing neuritic plaques and tau-positive neurofibrillary tangles and the loss of neurons in specified regions of the brain. Evidence suggests that increased levels/aggregation...

Fall 2020

Luki, Jessica

In the perimenopausal period, an event marked by end of menstrual cycle regularity, women are at a greater risk of either experiencing a reoccurrence of a major depressive episode (MDE), or presenting with their first MDE. This risk is greater in women with a history of mood vulnerability related...

Fall 2020

Brown, Jasmine M.

This dissertation explores the questions “What technology-based interventions are of most benefit in supporting the health and/or rehabilitation of individuals with substance use disorders? Where and how can they be most effectively embedded in the health system?” Chapter 1 begins with an...

Fall 2020

Chan, Eric Christopher

This thesis describes studies evaluating the predictive validity of suicide risk assessments, assessment and monitoring of bipolar disorder using mobile app-based self-report questionnaires, the feasibility and criterion validity of novel tools for the evaluation of suicidal ideation and...

Spring 2020

Wendlandt, Eszter

Myelin is an essential component of nervous system functioning: it supports axonal metabolism, enables saltatory conduction to allow for precise timing across cortical networks to regulate information processing and is increasingly recognized as an integral type of adult experience-dependent...

Fall 2020

Cheng, Catherine F

Multiple sclerosis (MS) is a complex and heterogeneous disease of the central nervous system (CNS) characterized by leukocyte infiltration, myelin damage, local gliosis, and axonal injury. Relapsing-remitting MS (RRMS) is the most common disease course. Although the pathogenesis remains unclear,...

Fall 2019

Gomez, Daniela Isabel

Despite the wide availability of effective antiretroviral therapy (ART), neurocognitive problems persist in over 20% of people living with HIV. Neurocognitive problems are highly heterogeneous in HIV, and the underlying etiology of neurocognitive impairment (NCI) is multifactorial. The...

Spring 2019

Malik, Manoj K

Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...