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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Srivastava, Nutan
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Aburahess, Salah
- 8Primary Biliary Cholangitis
- 7Inflammatory Bowel Disease
- 7Inflammatory bowel disease
- 6Endothelial cells
- 5Acute myeloid leukemia
- 5Mitochondria
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Identification of Natural Health Product-Associated Adverse Events and Natural Health Product-Drug Interactions in Adults and Children with Cancer
DownloadSpring 2022
Background: Patients with cancer frequently use natural health products (NHPs) to help treat cancer, reduce side effects, or improve effectiveness of conventional cancer treatment, and improve their quality of life. Often oncology healthcare providers do not inquire about NHP use, leading to low...
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The association between access to medical care (physicians and nurse practitioners) and impact on resident outcomes: A retrospective cross-sectional analysis
DownloadSpring 2022
The nursing home population is vulnerable and medically complex, yet little is known about models of medical service provision and associated quality outcomes. The goal of this thesis project is to examine the association between physician and nurse practitioner accessibility and practice...
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Exploring the Association Between Frailty and Adverse Clinical Outcomes in Inflammatory Bowel Disease
DownloadFall 2022
Background and Rationale: Chronological age does not always accurately reflect “biological age”, or the extent of physiological reserve an individual possesses to endure stressors. The concept of physiological reserve is best represented by frailty; a multifaceted syndrome or state that...
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Investigating Primary Biliary Cholangitis for a Human Betaretrovirus Superantigen signature
DownloadSpring 2022
Primary Biliary Cholangitis (PBC) is an idiopathic autoimmune disease characterized by destruction of small hepatic bile ducts and presence of antimitochondrial antibodies (AMA). A Human Betaretrovirus (HBRV) sharing 91-99% sequence similarity with the Mouse Mammary Tumor virus has been...
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Spring 2022
Allergens possessing serine proteinase activity like house dust mite (HDM) and cockroach can activate proteinase-activated receptor-2 (PAR-2), a pro-inflammatory G-coupled receptor. Par-2 -/- mice develop attenuated airway inflammation compared to WT mice. PAR-2 blockage in the airways abrogated...
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Understanding Heart Failure in Patients with Dilated Cardiomyopathy: A Direct Tissue Analysis from Explanted Human Hearts
DownloadFall 2022
Background Chronic heart failure (HF) remains a rising global epidemic that affects both adults and children population. The causes of HF are heterogeneous, and syndromes are often complicated by concomitant disorders such as iron deficiency (ID) and diabetes. Comorbidities not only complicate...
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Evaluation of Frailty Assessment Tools and their Measurement Properties in Chronic Kidney Disease
DownloadSpring 2022
Background: Frailty is three to seven times more common in people with chronic kidney disease (CKD) than in those with normal kidney function. Although frailty and its impact in CKD is well-recognized, the measurement properties of the tools used to assess this syndrome are not known. The aim of...
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Fall 2022
Background: Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease featuring beta-amyloid deposits within the cerebral vasculature. It is a major cause of cognitive decline and intracerebral hemorrhage in the elderly. A gap in knowledge surrounding mechanisms underlying CAA...
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Spring 2022
The endomembrane system is one of the hallmark features of all eukaryotes that distinguishes them from prokaryotes. Compared to bacteria and archaea, eukaryotic cells consist of biochemically and functionally distinct membranous compartments such as the endoplasmic reticulum, the Golgi apparatus,...