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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Logus, J. Wayne (John Wayne), 1951-
- 2Srivastava, Nutan
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 8Primary Biliary Cholangitis
- 7Inflammatory bowel disease
- 6Inflammatory Bowel Disease
- 5Acute myeloid leukemia
- 5Endothelial cells
- 4B cells
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Spring 2022
Allergens possessing serine proteinase activity like house dust mite (HDM) and cockroach can activate proteinase-activated receptor-2 (PAR-2), a pro-inflammatory G-coupled receptor. Par-2 -/- mice develop attenuated airway inflammation compared to WT mice. PAR-2 blockage in the airways abrogated...
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Fall 2022
Background The discovery of angiotensin-converting enzyme 2 (ACE2) introduced an alternative protective arm of the renin-angiotensin system (RAS), the ACE2/Angiotensin 1-7 (Ang 1-7)/Mas receptor axis, to counterbalance the more renowned pathogenic angiotensin-converting enzyme (ACE)/Angiotensin...
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Management of alcohol use disorder in cirrhosis: effect of a clinician-targeted alcohol use disorder in cirrhosis educational intervention on knowledge, attitudes, and practice habits
DownloadFall 2022
Introduction: Alcohol use disorder (AUD) is a common cause of liver cirrhosis. Low knowledge and comfort managing AUD among well-intentioned clinicians impacts the number of patients with cirrhosis who receive AUD treatment. Structured education focused on screening, brief intervention, referral...
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Isomaltodextrin dose-dependently reduces colitis development in HLA-B27 rat colitis model with associated changes to gut microbiota composition and short chain fatty acid production
DownloadFall 2021
Prevalence rates for inflammatory bowel diseases (IBD) worldwide have been drastically increasing over recent decades. IBD is characterized by altered intestinal microbiome (i.e. dysbiosis), described by reduced strict butyrate-producing anaerobes versus increased facultative anaerobes in...
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A Discrete Choice Experiment Pilot Study: Understanding Patient Preferences for In-centre Hemodialysis
DownloadFall 2021
Background: End-stage kidney disease (ESKD) is the failure of functioning kidneys such that they no longer have the capacity to sustain life without intervention. While the incidence of ESKD has remained generally stable across all ages of Canadians since 2000, the prevalence of ESKD has been...
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Fall 2021
Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease with unknown etiology that is characterized by inflammation and fibrosis of the intrahepatic and extrahepatic biliary tracts, leading to diffuse multifocal stricture formation. The pathogenesis of PSC is...
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Investigating the role of G-protein coupled receptor (GPCR) signaling as a potential target for anti-angiogenic therapy
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Angiogenesis is an essential process for normal growth and development whereby new blood vessels are formed from pre-existing ones. The balance between pro-angiogenic and anti-angiogenic growth factors is critical to maintain normal physiological condition. Prolonged activation of angiogenesis...
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Fall 2021
Primary Biliary Cholangitis (PBC) is a complex cholestatic liver disorder with both environmental and genetic factors that contribute to disease. While the etiology remains poorly understood, our lab continues to characterize the role of a human betaretrovirus (HBRV) in the disease process. Based...
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Construction and validation of a matrix for the estimation of exposures in the welding trades: a three-part series
DownloadSpring 2021
Galarneau, Jean-Michel, François
Introduction: This three-part series of papers aimed to construct and validate an exposure matrix that would be used to estimate personal airborne exposures to total dust, manganese, nickel, chromium and aluminum for welders in the What-me cohort. The Workers’ Health in Apprenticeship Trades:...
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Fabry Cardiomyopathy and Heart Failure: The Roles of Inflammation and Valvular Heart Disease
DownloadSpring 2021
Fabry disease (FD) is an X-linked recessive multisystem disorder and an underrecognized secondary cause of hypertrophic cardiomyopathy. A gene variant encoding the enzyme α-galactosidase A results in deficient or absent hydrolase activity, resulting in the accumulation of glycosphingolipids in...