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- 2Coulombe, Marilyne G.
- 2Logus, J. Wayne (John Wayne), 1951-
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Agrawal, Amogh
- 1Ahmed, Iqbal Hussein, 1953-
- 7Primary Biliary Cholangitis
- 6Inflammatory bowel disease
- 5Inflammatory Bowel Disease
- 4B cells
- 4Endothelial cells
Mitochondria generate reactive oxygen species (mROS) and metabolic substrates like alpha-ketogluterate (αKG), in proportion to oxygen, which target extra-mitochondrial effectors to coordinate a cellular response. For example, acute hypoxia decreases mROS, resulting in pulmonary artery smooth...
Atrial fibrillation is the most common arrhythmia and is increasing in prevalence worldwide. While it is not acutely life threatening, the complications of stroke and heart failure carry high mortality rates and extensive healthcare costs. Healthcare leaders have identified the extra demands...
Development of a Novel Piglet Model to Simulate the Physiology of a Child with Hypoplastic Left Heart Syndrome during the First Interstage for Investigating Changes in Tricuspid Valve as it Adapts to a High-pressure and High-volume Stress EnvironmentDownload
INTRODUCTION: Tricuspid valve (TV) failure develops in 25-35% of children with hypoplastic left heart syndrome (HLHS) and is a risk factor for morbidity and mortality. The mechanisms underlying TV failure in HLHS are not well understood. There is no effective medical therapy and current surgical...
Rationale: Eosinophils are “end cell” leucocytes, associated with allergy, asthma and helminthiasis. At sites of inflammation, eosinophils may modulate immune response through expression of the extra-hepatic tryptophan-catabolising enzyme, Indoleamine 2, 3-dioxygenase (IDO). Kynurenines, products...
Heart failure is common, and is associated with significant mortality, morbidity, and reduced quality of life. The objective of this thesis is to evaluate some therapeutic interventions and outcomes in patients with acute and chronic heart failure. In the first part, the efficacy of cardiac...
Cytomegalovirus (CMV) is the most common opportunistic post-transplant infection. Although important advances have been made in the management and prevention of post-transplant CMV, current strategies for monitoring and prevention still show significant limitations. Such gaps create opportunities...
Human Pegivirus Infection of the Central Nervous System: Neural Cell Tropism and Neuroimmune ResponsesDownload
Human pegivirus (HPgV) is a positive sense, single-stranded RNA virus of the Flaviviridae family that is best characterized in the context of peripheral lymphocyte infection. Our group recently reported HPgV infection in the central nervous system (CNS) of two patients with fatal...
Background: Fecal Microbial Transplantation (FMT) has gained popularity due to its efficacy in the treatment of recurrent Clostridium difficile infection (RCDI). RCDI is associated with prolonged courses of antibiotics with high recurrence rates following the initial resolution of symptoms. ...