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- 2Coulombe, Marilyne G.
- 2Logus, J. Wayne (John Wayne), 1951-
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Aburahess, Salah
- 1Agrawal, Amogh
- 8Primary Biliary Cholangitis
- 7Inflammatory bowel disease
- 6Inflammatory Bowel Disease
- 5Endothelial cells
- 4B cells
- 4Crohn's disease
Background: NK cells are a key cellular component of antibody-mediated rejection (ABMR), but their role in ABMR has not been identified. We postulated that NK cells are stimulated through their CD16a antibody receptors by donor-specific anti-HLA antibodies in ABMR. There is currently no direct...
The Impact of Complications of Cirrhosis in Patients Undergoing Cardiac Surgery: A Propensity Matched Cohort StudyDownload
Background: Patients with cirrhosis and concomitant coronary/valvular heart disease present a clinical dilemma. Cardiac surgeons often are reluctant to operate in this high-risk population, potentially diminishing survival/potential for liver transplant. This study aimed to identify associations...
Investigating the Role of Paralogous Gene Expansion and Functional Homology of Membrane-Trafficking Machinery in Organellogenesis: Apicomplexan Parasites as a Model CaseDownload
The ease with which large multicellular organisms, such as plants and animals, may be observed belies an unappreciated wealth of diversity; the majority of eukaryotes are unicellular, and display a dazzling array of morphologies and lifestyles. Some eukaryotes are free-living or symbiotic,...
Introduction: Inflammatory bowel disease (IBD), which is consisted of ulcerative colitis (UC) and Crohn’s disease (CD), is a relapsing-remitting inflammatory condition of gastrointestinal tract. Although the exact pathophysiology of IBD is not known yet, it has been suggested that a combination...
The BETA-2 Score: a Tool for Assessing Beta Cell Function in Clinical Islet Transplantation and Type 1 Diabetes Intervention TrialsDownload
Preservation of beta cell function is integral to clinical islet transplantation (CIT) and in the development of treatments which halt the progression of type 1 diabetes (T1D). Outcome assessment remains difficult in both fields as the preservation of beta cell function and maintenance of glucose...
The two types of rejection identified in the Banff histopathologic diagnosis are T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR). TCMR is most common early post-transplant while ABMR is the main cause of late graft loss. Kidney transplant TCMR is diagnosed histologically...
Human betaretrovirus (HBRV) infection has been characterized in patients with primary biliary cholangitis (PBC). Our lab has documented HBRV proviral integrations in bile ducts of PBC patients. However, serological diagnostics cannot detect HBRV infection in the majority of PBC patients, limiting...