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Skip to Search Results- 2Coulombe, Marilyne G.
- 2Kinnaird, Adam
- 2Srivastava, Nutan
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Aburahess, Salah
- 8Primary Biliary Cholangitis
- 7Inflammatory bowel disease
- 6Inflammatory Bowel Disease
- 5Acute myeloid leukemia
- 5Endothelial cells
- 4B cells
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Fall 2020
Background: Abundant evidence links the built environment (BE) and physical activity levels in older adults. Yet, the relationship of BE and other domains that are conducive for healthy aging and aging in place, have been insufficiently studied. This study investigated the relationship of...
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Fall 2014
Epidemiological studies correlate vitamin D deficiency with asthma severity. Calcitriol modulates receptor and cytokine expression from various leukocytes in an anti-inflammatory manner. Despite eosinophil activity during mucosal inflammation, knowledge on the direct effect of calcitriol on this...
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Utility of Screening-Bead Assay in Testing for Formation of Donor-Specific Anti-HLA Antibodies and Antibody-Mediated Rejection in Renal Allografts Post-Transplant.
DownloadFall 2020
Background: Present-day immunosuppressive therapy in renal allograft recipients targets cell-mediated immunity and has significantly improved outcomes over the years. However, allograft failure rates still approach 50% towards 10 years post-transplantation. Antibody-mediated rejection (ABMR) is...
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Fall 2018
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality and have placed a significant burden on our society both regionally and globally. With the development of information technology, we are accumulating digitalized data at an exponential speed. This growing volume of...
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Fall 2018
Inflammatory bowel diseases (IBD) are a group of chronic inflammatory conditions including ulcerative colitis (UC) and Crohn’s disease (CD) induced by an interaction between genetic susceptibility, environmental factors, dysbiosis of gut microbiota and an abnormal mucosal immune response....
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Use of Guideline-directed Medical Therapy in Patients ≥65 years after the Diagnosis of Heart Failure: A Canadian Population-based Study
DownloadFall 2023
Background: Guideline-directed medical therapy (GDMT) improves clinical outcomes in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Despite proven efficacy, GDMT are under-utilized in clinical practice. The current study examines GDMT utilization after incident...
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Unveiling the pathway for the nuclear translocation of the large mitochondrial enzyme Pyruvate Dehydrogenase Complex (PDC)
DownloadSpring 2021
Pyruvate dehydrogenase complex (PDC) is a mitochondrial enzyme that links glycolysis to oxidative phosphorylation by decarboxylating glucose-derived pyruvate to produce acetyl-CoA that is used in the Krebs cycle. PDC was initially thought to reside only in the mitochondrial matrix but we recently...
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Understanding the Context of Pharmacy Practice Change: Gaining insight into the professional culture of pharmacy and pharmacists’ personality
DownloadFall 2014
Background: Pharmacists around the world are being asked to adopt, and integrate, an increasing number of clinical services into their practices. Evidence for the efficacy of pharmacists’ interventions in patient care also continues to grow. Traditional approaches to understanding practice change...
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Understanding Heart Failure in Patients with Dilated Cardiomyopathy: A Direct Tissue Analysis from Explanted Human Hearts
DownloadFall 2022
Background Chronic heart failure (HF) remains a rising global epidemic that affects both adults and children population. The causes of HF are heterogeneous, and syndromes are often complicated by concomitant disorders such as iron deficiency (ID) and diabetes. Comorbidities not only complicate...