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- 24Chemistry
- 23Organic compounds. Synthesis.
- 22Metabolomics
- 21Capillary electrophoresis.
- 21Catalysis
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Development of an enantioselective two-dimensional liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry method for the analysis of methylsulfonyl polychlorinated biphenyls in tissue extracts
DownloadSpring 2011
An enantioselective heart-cut two-dimensional liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry method was developed for the analysis of 25 methylsulfonyl polychlorinated biphenyl metabolites in tissue extracts. Enantioseparation was achieved for 9 out of the 10...
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Development of Blood Metabolomics for Biomarker Discovery Using Chemical Isotope Labeling and Liquid Chromatography-Mass Spectrometry
DownloadSpring 2018
Blood-metabolite-based biomarkers are useful for the early-stage diagnosis, accurate prognostic prediction and personalized treatment of various diseases. Blood contains a massive number of metabolites that can potentially become biomarkers, but the metabolome coverage of current analytical...
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Spring 2010
Nanoscale patterning of organic molecules has received considerable attention in current nanoscience for a broad range of technological applications. In order to provide a viable approach, this thesis describes catalytic stamp lithography, a novel soft-lithographic process that can easily...
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Development of Chemical Isotope Labeling (CIL) LC-MS Techniques for Untargeted Analysis Milk Metabolomics and Targeted Analysis of Propionic Acid
DownloadFall 2017
Metabolomics is the study of all the small molecules in a given sample or organism. It is used to understand individual variations caused by the relationship between the individual’s genetics, exposome and metabolic activity. There is interest in using metabolomics for personalized care leading...
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Development of Chemical Isotope Labeling (CIL) Liquid Chromatography-Mass Spectrometry (LC-MS) for Single-Cell Metabolomics
DownloadFall 2021
Single-cell metabolomics (SCM) strives to identify, quantify and characterize all metabolites in a single-cell. The study of the metabolome enhances our understanding of the cellular interaction with and in response to environmental influences at the molecular level. As cells are being analyzed...
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Development of Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Cellular Metabolomics
DownloadFall 2018
Cellular metabolomics is the global study of a whole set of metabolites and its chemical processes in cells. Different analytical platforms, such as NMR and MS, have been employed for profiling the highly complex cellular metabolome and various data processing approaches have been developed. ...
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Development of Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry on Quadrupole-Orbitrap Mass Spectrometers for Metabolome Analysis
DownloadFall 2023
Chemical isotope labeling liquid chromatography-mass spectrometry (CIL LC-MS) is a powerful technique in metabolomics, offering extensive coverage of the metabolome. This method involves dividing metabolites into sub-groups based on their functional groups and subjecting them to specific labeling...
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Spring 2013
The discovery of green fluorescent protein (GFP) from the Aequorea victoria jellyfish revolutionized many fields in the scientific community, including molecular biology, protein engineering, and neuroscience. The ability to genetically link a fluorescent protein to a protein of interest has...
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Development of Cu-Catalyzed Decarboxylative Heteroarylation and Rh-Catalyzed Carbene Olefination
DownloadFall 2017
Transition metal-catalyzed cross-coupling reactions are widely used transformations to generate useful chemicals. The development of new variants for transition metal-catalyzed cross-coupling reactions provides more efficient methods for the construction of functionalized molecules. This thesis...