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- 2Li, Leo
- 2Nizio, Katie D
- 1Abdel Latif Ibraheem, Ahmed Abdel Mohsen
- 1Abdelfattah, Ahmed
- 1Abel, Robin Jacob
- 1Abou-Ghanem, Maya
- 23Organic compounds. Synthesis.
- 21Capillary electrophoresis.
The study of target proteins in live cells is fundamentally important to understanding their molecular roles in biological processes. Applications of cell permeable small molecules in bioorthogonal reactions have been improved to selectively label proteins tag for the purpose of protein...
In this thesis, the results of high resolution molecular spectroscopic studies of several prototype molecular complexes containing either water or ammonia molecule and the instrumentation development of an infrared spectrometer which is used to carry out the main part of the experimental work are...
Development and Applications of Chemical Isotope Labeling Methods for Metabolome Sample Normalization and Liquid Chromatography-Mass Spectrometry-Based MetabolomicsDownload
Metabolomics refers to the global study of the metabolome of a biological system where comprehensive and systematic profiling of all metabolites in a given biological sample (i.e., the metabolome) is performed. As the end product of biological processes, the status of metabolites could reflect...
Graphitic carbon phases for chelation chromatography and electrochemically modulated preconcentrationDownload
The first part of this thesis explores the synthetic method that converts carbon clad zirconia particles into chelation stationary phase. Oxine groups were attached onto the graphitic carbon surface by in situ generated diazonium ions in the aqueous solution. XPS, FTIR, SEM were utilized to...
Investigation of the Synthesis, Reactivity and Biological Properties of Various 6-Substituted D-Fructose DerivativesDownload
The detection of small tumors growing in complex organs, including breast tissue, is a challenge in modern medical imaging. The use of positron emission tomography (PET) and tracer molecules containing radionuclei such as 18F have been of significant value to detect small tumors. The commonly...
Pyridoxal phosphate (PLP)-independent racemases, enzymes that are cofactor and metal free invert, the configuration at the α-carbon of amino acids. In nature, diaminopimelate epimerase (DapF), glutamate racemase (GluR), aspartate racemase (AspR), proline racemase (ProR), O-ureidoserine racemase...
Synthesis and Characterization of Cross-Conjugated Macrocycles and Exploratory Study of their Organometallic ChemistryDownload
This thesis covers the synthesis, characterization and physical studies of cross-conjugated macrocycles, expanded radialenes, as well as their related derivatives. The main synthetic protocol that is used throughout this thesis is based on the Pd-mediated Sonogashira cross coupling reaction of a...