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Skip to Search Results- 2Chun, Justin
- 1Aktary, Zackie M
- 1Anderson, Andrea Marie
- 1Anderson-Baron, Matthew N
- 1Armstrong, Heather K
- 1Baier, Alicia
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Spring 2015
Nuclear pore complexes (NPCs) form aqueous portals in the nuclear envelope (NE) and are the sole sites for molecular exchange between nuclear and cytoplasmic compartments. While ions, small metabolites and molecules under ~40 kDa can freely passage through NPCs, most macromolecular transport...
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Fall 2010
Peroxisomes are indispensable organelles that perform many essential metabolic activities. Thus, eukaryotic cells have evolved molecular mechanisms to ensure the inheritance of peroxisomes from mother cell to daughter cell at cell division. In the budding yeast Saccharomyces cerevisiae, the class...
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Investigating the roles of phosphorylation in modulating Argonaute 2 activity and localization
DownloadSpring 2017
RNA interference (RNAi) has enabled the study of gene function with unprecedented specificity and reliability. Almost twenty years after the discovery of RNAi, we now know that this process is carried out by a set of evolutionarily conserved proteins. In mammals, these proteins form part of the...
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Investigation of Hsp90 Regulation by the Aha-type Co-chaperones: Mechanistic Insight into Two Conserved Motifs
DownloadSpring 2019
Hsp90 is a highly conserved and essential molecular chaperone. It regulates the folding, maturation, and activation of client proteins involved in a wide range of cellular processes and pathways, many of which are key players in disease. Hsp90 functions in the context of an ATPase driven...
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Investigation of mRNP export kinetics and gene expression regulation by the DEAD-box protein Dbp5p in Saccharomyces cerevisiae
DownloadFall 2019
The intricate architecture of the eukaryotic cell, which includes the partitioning of the cell into discrete membrane bound organelles, necessitates that various cargos must cross the nuclear envelope (NE). Nuclear pore complexes (NPCs) are large macromolecular assemblies embedded within the NE...