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- 1Aktary, Zackie M
- 1Anderson-Baron, Matthew N
- 1Armstrong, Heather K
- 1Baier, Alicia
- 1Bodman, James A. R.
- 1Brown, Trevor Wayne.
Cells require the ability to modulate function in response to their surroundings so that they are able to contribute to the survival of the organism. A key mechanism that allows tunable responses to changes in environment is by differential control of gene expression by transcriptional...
Understanding the evolution of the membrane trafficking system in diverse eukaryotes through comparative genomics and transcriptomicsDownload
Single-celled organisms represent the majority of eukaryotic diversity. Recent advances in sequencing technologies have been critical for understanding the evolutionary biology and cell biology of microbial eukaryotes. Comparative genomic analyses have shown that many genes that underlie...
In yeast, subtelomeric chromatin is silenced and positioned at the inner nuclear membrane (INM) through the interaction of proteins that comprise the heterotrimeric SIR complex with INM proteins. Telomeres reside primarily at the INM using partially redundant tethering mechanisms mediated by the...
Mast cells are tissue-resident immune cells that undergo exocytosis upon activation, releasing potent immunoregulatory molecules that initiate inflammatory responses. Here, I investigated the role of the hematopoietic specific Rho GTPase, Rac2, and the ubiquitous, Rac1, on mast cell exocytosis....
The Peroxin Pex34p Functions with the Pex11 Family of Proteins to Regulate the Peroxisome Population in the Yeast Saccharomyces cervisiaeDownload
Peroxisomes are highly dynamic organelles that change in size and number in response to both intra- and extracellular cues. Peroxisome growth and division are controlled by the import of matrix proteins and by a specialized divisional machinery that includes peroxisome-specific factors, such as...
The Drosophila GW protein, a posttranscriptional gene regulator that influences progression through mitosisDownload
Regulation of mRNA translation and stability can occur in cytoplasmic compartments known as mRNA processing bodies or P bodies. These compartments contain factors that function in multiple mRNA regulatory pathways and are thought to be centres for coordinating the action of these pathways. One...
The Biochemical Characterization of the ATPase activity of three Hsp82 point mutants: Hsp82pA587T, Hsp82pG313S, and Hsp82pE381KDownload
Chaperones are family of proteins that assist in protein folding. 90 kDa Heat shock protein (Hsp90 mammalians, Hsp82 in Saccharomyces cerevisiae) is a well conserved chaperone that is essential for eukaryotic viability. The Hsp90 cycle is regulated by the ability to hydrolyze ATP, and through the...
Zika virus is a positive-sense RNA virus belonging to the Flaviviridae family of viruses, which include Dengue, Yellow Fever, Hepatitis C and West Nile viruses. Growing evidence suggests viral infection results in the subversion of numerous host cell factors to aid in viral replication. Despite...
Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in HepatocytesDownload
Triacylglycerol (TG) metabolism with its high-energy potential is stringently regulated. Unbalanced TG regulation, either too much TG that overwhelms cellular storage capacity or too little TG due to defects in adipogenesis, is associated with various metabolic disorders. TG can be exported from...