The Peroxin Pex34p Functions with the Pex11 Family of Proteins to Regulate the Peroxisome Population in the Yeast Saccharomyces cervisiae

  • Author / Creator
    Tower, Robert J
  • Peroxisomes are highly dynamic organelles that change in size and number in response to both intra- and extracellular cues. Peroxisome growth and division are controlled by the import of matrix proteins and by a specialized divisional machinery that includes peroxisome-specific factors, such as members of the Pex11 protein family, and general organelle divisional factors, such as the dynamin-related protein Vps1p. Here we show that Pex34p is a peroxisomal integral membrane protein that acts independently and together with the Pex11 protein family members Pex11p, Pex25p and Pex27p to control the peroxisome populations of cells under conditions of both peroxisome proliferation and constitutive peroxisome division. Pex34p can act as a positive effector of peroxisome division but requires the Pex11 family proteins. Our addition of Pex34p to the repertoire of proteins involved in regulating peroxisome division emphasizes the necessity of cells to strictly regulate their peroxisome populations.

  • Subjects / Keywords
  • Graduation date
  • Type of Item
  • Degree
    Master of Science
  • DOI
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
  • Institution
    University of Alberta
  • Degree level
  • Department
    • Department of Cell Biology
  • Supervisor / co-supervisor and their department(s)
    • Dr. Richard Rachubinski (Cell Biology)
  • Examining committee members and their departments
    • Dr. Gary Eitzen (Cell Biology)
    • Dr. Michael Schultz (Biochemistry)