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Skip to Search Results- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
- 1Alabi, Adekunle
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Spring 2024
Matrix metalloproteinase 2 (MMP2), also known as gelatinase A or 72 kDa type IV collagenase, is a member of a family of 25 different Zn2+-dependent endopeptidases that cleave a broad range of proteins including extracellular matrix proteins (such as collagens, laminin, fibrillin and aggrecan),...
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Fall 2023
When calcium enters the cytosol of a muscle cell from the SR, it initiates muscle contraction, while its removal by the sarco(endo)plasmic reticulum calcium ATPase (SERCA) induces muscle relaxation. SERCA's activity is regulated by Phospholamban (PLN), which can reversibly inhibit its apparent...
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Measuring proteomic changes associated with viral infections and neurodegenerative diseases using mass spectrometry
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Viral infection and the resultant cellular stress can trigger significant changes to the cellular host proteome. Viral proteases essential to viral replication have been shown to cleave human host protein substrates as a mechanism of immune response evasion. The severe acute respiratory syndrome...
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Fall 2023
Lipids are integral components of all cells. Lipid molecules form the membrane and control membrane integrity while storage lipids act as a source of energy for the cell. The chemical properties of lipids are determined by the composition of the molecule’s acyl chain moieties. Incorporation of...
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Role of MMF1 Gene in Mannosylerythritol Lipid Secretion and Sustainable Biosurfactant Production from Brackish Water
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This thesis investigates the secretion of mannosylerythritol lipid (MEL) in the JCM10317 strain of P. antarctica, and the potential for a more cost-effective, environmentally friendly production process for MEL. The study demonstrates that the Pa MMF1 gene is necessary for the secretion of...
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Novel Isotope Labeling Strategies for NMR-Based Structure Determination of High Molecular Weight Proteins
DownloadSpring 2023
Solution NMR studies of high molecular weight proteins suffer from inadequate side-chain information and rapid signal decay. Selective 1H, 13CH3-methyl labelling of perdeuterated proteins has been the standard approach addressing these limitations but suffers from a lack of information about the...
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Fall 2022
Calnexin is a type 1 integral endoplasmic reticulum (ER) membrane protein and molecular chaperone involved in the folding and quality control of membrane associated and secreted proteins. The ER luminal domain of calnexin is responsible for the chaperone function, whereas the C-terminal domain is...
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Fall 2022
While great advancements have been made in the field of tau biology, one particularly elusive component is the significance of structural variance of tau aggregates linked to disease: we see great structural heterogeneity among the aggregates obtained from various tauopathies despite being made...
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Fall 2022
Prion diseases are neurodegenerative disorders that arise from the misfolding of the cellular prion protein (PrPC) into the infectious prion protein (PrPSc), resulting in a conformational change in the protein structure. Despite being extensively studied, high-resolution structural information...
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Tau seeding in a HEK cell model is influenced by aggregation inducers and cellular chaperones
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The tau protein is a microtubule associated protein whose misfolding and subsequent aggregation have been associated with a group of neurodegenerative diseases known as tauopathies. Studying tau in a lab setting has been crucial for the advancement of knowledge and technology used to treat people...