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Skip to Search Results- 2Veldhoen, Richard
- 1ALSHUMAIMERI, NADA A.
- 1Acevedo Morantes, Claudia Y
- 1Aderibigbe, Ayodeji O.
- 1Ahsan, Irfan.
- 1Alabi, Adekunle
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Measuring proteomic changes associated with viral infections and neurodegenerative diseases using mass spectrometry
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Viral infection and the resultant cellular stress can trigger significant changes to the cellular host proteome. Viral proteases essential to viral replication have been shown to cleave human host protein substrates as a mechanism of immune response evasion. The severe acute respiratory syndrome...
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Role of MMF1 Gene in Mannosylerythritol Lipid Secretion and Sustainable Biosurfactant Production from Brackish Water
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This thesis investigates the secretion of mannosylerythritol lipid (MEL) in the JCM10317 strain of P. antarctica, and the potential for a more cost-effective, environmentally friendly production process for MEL. The study demonstrates that the Pa MMF1 gene is necessary for the secretion of...
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Fall 2023
Lipids are integral components of all cells. Lipid molecules form the membrane and control membrane integrity while storage lipids act as a source of energy for the cell. The chemical properties of lipids are determined by the composition of the molecule’s acyl chain moieties. Incorporation of...
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Fall 2023
When calcium enters the cytosol of a muscle cell from the SR, it initiates muscle contraction, while its removal by the sarco(endo)plasmic reticulum calcium ATPase (SERCA) induces muscle relaxation. SERCA's activity is regulated by Phospholamban (PLN), which can reversibly inhibit its apparent...
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Spring 2022
Primary herpes simplex virus 1 (HSV-1) infections are common in childhood, affecting mainly the oropharyngeal mucosa. The virus is then transported to the neuronal bodies in the trigeminal ganglia, where it establishes lifelong latency. Although latent infections are asymptomatic, HSV-1...
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Fall 2022
Metabolic enzymes are active in both the nucleus and cytoplasm. While metabolism in cytoplasm is widely acknowledged for energy production, nuclear-localized metabolic enzymes are thought to modulate availability of metabolites used in epigenetics. A thorough investigation of this regulatory...
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Structural insight of transcriptional terminator recognition by ProQ/FinO domain RNA chaperones
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The ProQ/FinO family is an emerging group of RNA binding proteins that are critical for sRNA-mediated gene regulation in proteobacteria. The ProQ/FinO domain of these proteins recognizes a transcriptional terminator, hairpin-tail structure, to regulate gene expression. The important role of the...
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Spring 2022
Eukaryotes feature a split gene structure in which pre-mRNAs are spliced into mature RNAs prior to the translation of proteins. The splicing process is catalyzed by a dynamic multi-subunit molecular machine known as the spliceosome that assembles in a stepwise fashion. An early complex formed in...
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Spring 2022
The DNA damage response (DDR) is critical for maintaining genomic integrity and prevention of genotoxic consequences leading to carcinogenesis. The DDR signaling cascade results either in the activation of the repair pathway, or initiation of apoptosis if the repair is not possible. Many...
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Fall 2022
While great advancements have been made in the field of tau biology, one particularly elusive component is the significance of structural variance of tau aggregates linked to disease: we see great structural heterogeneity among the aggregates obtained from various tauopathies despite being made...