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Characterization of eNOS-based Platelets Subpopulations in COVID-19 and the Impact of Platelet α-Granule Contents on Cancer Cell PD-L1
DownloadFall 2024
Thrombosis significantly complicates numerous diseases that have inflammatory components. This condition, characterized by the formation of blood clots within blood vessels, can exacerbate a range of health issues, from cardiovascular diseases to systemic infections like COVID-19, and even...
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Pharmacological Characterization of Calcium-Activated Potassium Channel Function in Human Platelets
DownloadSpring 2019
Background: Platelets and endothelial cells play an important role in maintaining vascular tone and hemostasis, critical to maintaining the health of the cardiovascular system. In resistance arteries, stimulation of endothelial cell small (SKCa) and intermediate (IKCa) conductance...
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The Role of the Androgen Receptor in Prostate Cancer-induced Platelet Aggregation and Invasion
DownloadFall 2019
Background: Prostate cancer (PCa) is the most common visceral malignancy and third leading cause of cancer death among men in Canada. The 2018 Canadian Cancer Society estimates suggest that 21,300 men were diagnosed and 4,100 patients died of this disease. Metastatic prostate cancer (mPCa) is...