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Skip to Search Results- 2Kinnaird, Adam
- 1Beaulieu-Bayne, Emilie
- 1Bhullar, Khushwant Singh
- 1Fine, Eugene J.
- 1Lam, Victoria Hol Mun
- 1Mattingly, Stephanie
- 13Graduate and Postdoctoral Studies (GPS), Faculty of
- 13Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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A Nutritional Perspective of Ketogenic Diet in Cancer: A Narrative Review
2018-04-01
Oliveira, Camila L. P., Mattingly, Stephanie, Schirrmacher, Ralf, Sawyer, Michael B., Fine, Eugene J., Prado, Carla M.
The predominant use of glucose anaerobically by cancer cells (Warburg effect) may be the most important characteristic the majority of these cells have in common and, therefore, a potential metabolic pathway to be targeted during cancer treatment. Because this effect relates to fuel oxidation,...
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Fall 2024
Astrocytes can store excess fatty acids in lipid droplets to avoid lipotoxicity. Fatty acids can be released from lipid droplets and catabolized to generate energy in the mitochondria. We previously found reduced astrocytic lipid droplets and increased transport of fatty acids into the...
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Fall 2023
Proliferating cells, such as neonatal cardiomyocytes, have a high Warburg effect, which is a metabolic state in which there is high rates of glycolysis uncoupled from glucose oxidation under aerobic conditions. The Warburg effect is typically seen in cancerous cells and actively proliferating...
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Effects of Tripeptide IRW (Ile-Arg-Trp) on metabolism, mitochondrial biogenesis, and lifespan extension
DownloadSpring 2022
Bioactive tripeptide IRW (Ile-Arg-Trp) was initially identified as an ACE (angiotensin-converting enzyme) inhibitory peptide from egg protein ovotransferrin. The pharmacological spectrum of IRW extends towards metabolic boosting and anti-diabetic properties as well. The overall objectives of this...
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Fall 2019
Background: Diabetes is characterized by dysregulated glucose homeostasis that leads to hyperglycemia, due in part to increased hepatic glucose production (GP) and insulin resistance. Excessive levels and/or action of glucocorticoids (GCs) are associated with obesity, insulin resistance, and...
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Inflammation, Oxidative Stress, Metabolic Inefficiency, And Related Functional Decline of the Heart During Ex-situ Perfusion
DownloadSpring 2021
Normothermic ex-situ heart perfusion (ESHP) is an emergent technique that allows for continued perfusion of the beating heart, supplying required oxygen and nutrients. Also, this technique offers a venue to assess the metabolic and functional viability of the donated heart during the period of...
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Spring 2019
Dramatic maturational changes occur in heart energy metabolism in the fetal to newborn transition, most predominantly marked by a decrease in glycolysis and an increase in fatty acid oxidation which then becomes the major energy providing substrate for the heart after birth. However, in the...
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Membrane Type 1 Matrix Metalloproteinase Cleaves Low Density Lipoprotein Receptor to Regulate Lipid Metabolism
DownloadFall 2022
Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol (LDL-C) and protects against the development of atherosclerosis. Our previous studies demonstrated that membrane type-1 matrix metalloproteinase (MT1-MMP/MMP14) cleaves LDL receptor (LDLR) and exacerbates the...
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Spring 2018
Renal cell carcinoma comprises approximately 2-3% of all malignancies, with the majority, approximately 70%, being clear cell renal cell carcinoma (ccRCC). ccRCC features many cancer hallmarks such as suppressed mitochondrial glucose oxidation, apoptosis-resistance, angiogenesis, immune evasion,...
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Spring 2018
Renal cell carcinoma comprises approximately 2-3% of all malignancies, with the majority, approximately 70%, being clear cell renal cell carcinoma (ccRCC). ccRCC features many cancer hallmarks such as suppressed mitochondrial glucose oxidation, apoptosis-resistance, angiogenesis, immune evasion,...