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Skip to Search Results- 1Hu, Qian
- 1Kelly, Rees G
- 1Konowalchuk, Jeffrey
- 1Lee, Megan CMH
- 1Parkes, Michael D
- 1Smolarchuk, Christa
- 1Agrawal, Babita (Surgery)
- 1Anderson, Colin (Surgery and Medical Microbiology and Immunology)
- 1Baldwin, Troy (Department of Medical Microbiology and Immunology)
- 1Baldwin, Troy (Medical Microbiology and Immunology)
- 1Baldwin, Troy (Medical Microbiology and Immunology)
- 1Clemente-Casares, Xavier (Medical Microbiology and Immunology)
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The role of obesity and insulin resistance in modulating immune cell function in cancer and liver disease
DownloadFall 2023
Obesity and associated insulin resistance (IR) represent a significant global health burden, and predispose individuals to develop various diseases, including cancer and liver diseases. Heightened inflammation during obesity can on the one hand exacerbate liver inflammation, while on the other,...
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T Cell Generation in a Lymphopenic Environment Generates Disease when the Thoracic Thymus is Eliminated; Augmentation by IL-7/Anti-IL-7 Complexes
DownloadSpring 2012
Cervical thymus functionally mimics the thoracic thymus in supporting T cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus generates an overall repertoire of T cells that are self-tolerant similar to the thoracic thymus. Mice...
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Fall 2016
Background: NK cells are a key cellular component of antibody-mediated rejection (ABMR), but their role in ABMR has not been identified. We postulated that NK cells are stimulated through their CD16a antibody receptors by donor-specific anti-HLA antibodies in ABMR. There is currently no direct...
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Fall 2009
MUC1, a protein of epithelial and carcinoma cells, has recently been shown on activated T cells where it inhibits CD3-stimulated proliferation. Two immunoregulatory domains similar to ITAM and ITIMs are present on its cytoplasmic tail, suggesting that MUC1 can act as both a costimulatory and...
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Fall 2019
T cells are a vital part of the adaptive immune system that function to eliminate foreign threats while remaining tolerant to healthy-self. During T cell development in the thymus, T cells are generated with various T cell receptor (TCR) specificities, such that they can respond to a near endless...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Characterizing tolerance in CD8 T cells in the absence of Bim-mediated clonal deletion to tissue restricted antigens
DownloadFall 2016
T cells are part of the adaptive immune system that eliminate pathogen-infected cells, but do not harm healthy cells. Precursor T cells, termed thymocytes, develop in the thymus where they randomly generate and express unique antigen specific T cell receptors (TCR) during the CD4+CD8+ double...