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Gait and Cognition: Exploring Cognition and Dual-task Costs in a Group of Community Dwelling Alzheimer’s Disease Patients over 6 Months
DownloadFall 2022
Alzheimer’s disease is a progressive neurological disorder resulting in cognitive decline affecting many activities of daily living including gait. Many tools exist to monitor AD progression, including cognitive examinations, and functional tests of mobility. The purpose of the present study is...
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Characterizing physical activity documentation patterns and curriculum of Canadian family physicians
DownloadFall 2022
Family physicians (FP) can be meaningful advocates to support patients to attain the benefits of physical activity (PA); however, the PA-related documentation FPs make in electronic medical records (EMR) is largely unknown. The purpose of this dissertation was to conduct three studies: to examine...
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Thermal response of amyloidogenic elements in cultured N2a cells: potential relevance to Alzheimer’s disease pathology
DownloadFall 2020
Alzheimer’s disease (AD) weighs a large burden on health care systems, families and caregiving networks around the world. It is the most common dementia afflicting elderly individuals, and causes many debilitating symptoms, including memory loss, mood swings and confusion which progress in...
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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Putative ante-mortem indicators of Alzheimer’s dementia: Analysis of fluid biomarker and neuroimaging studies
DownloadSpring 2019
Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...
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Fall 2019
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid beta (Aβ) peptide. It has been proposed that AD pathology is transmissible by a “prion-like” mechanism through extracellular vesicles (EVs) that contain Aβ. In this context, EVs describe both microvesicles and exosomes,...
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An Investigation of Integrating Program- and System-level Datasets for Examining Relationships Among Variables of a Complex Health System
DownloadFall 2017
The potential for integrated program- and system-level datasets for generating previously inaccessible evaluative insights remains untapped. This study, situated within a yearlong evaluation of a lifestyle intervention program for patients with metabolic syndrome (MetS), provides an illustrative...
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Common Conditions in Primary Care and Minimal Clinically Important Differences on Depression Scales
DownloadFall 2017
Primary care has the highest patient volume and the greatest complexity of illness compared to other specialties and levels of health care. Although local data are available, a global perspective on the most common reasons for consulting primary care is lacking. Identifying these conditions would...
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Zebrafish Targeted Mutagenesis to Unveil Normal Physiological Functions of, and Interactions between, Prion Protein (PrP) and Amyloid Precursor Protein (APP): Relevance to Alzheimer’s disease
DownloadSpring 2017
Much of the work on Prion Protein (PrPC) and Amyloid Precursor Protein (APP) biology has focused on the contributions of their misfolded forms or aggregated metabolites to prion diseases and Alzheimer’s disease, respectively. As subversion/partial loss of some normal functions are also likely...
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Benefits and Challenges of Implementing an Electronic Medical Record System in an Urban Slum in Kenya
DownloadSpring 2016
This Thesis consists of two papers that explore the use of Electronic Medical Record (EMR) systems in resource-limited settings. The first paper (Chapter 2) comprises a State-of-the-Art review of the types of inquiry, settings, interventions and principal findings reported from studies of the...