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Fall 2013
Axenfeld-Rieger syndrome (ARS) is a rare developmental disease that affects structures in the anterior segment of the eye. Approximately 50% of ARS patients develop glaucoma, a progressively blinding condition. Although glaucoma is an aging-related disease, ARS patients usually have earlier-onset...
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Insights into the Transcriptional Regulation and Physiological Importance of Phosphatidylethanolamine N-Methyltransferase
DownloadSpring 2010
Phosphatidylcholine (PC) is made in all nucleated mammalian cells via the CDP-choline pathway. Another major pathway for PC biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). We have identified 3T3-L1 adipocytes as a cell culture model that expresses PEMT...
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Investigation of BCL-2 interacting killer (BIK) as a breast cancer biomarker and its role in failed apoptosis
DownloadSpring 2019
Breast cancer is the number one cause of cancer-associated deaths in women worldwide. It can be broadly classified into estrogen receptor (ER) positive or -negative subtypes which form the basis of treatment. Despite the therapeutic advancements, more than half a million women annually succumb to...
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Fall 2011
Aromatic amines during peroxidase metabolism produce N-centered cationic radicals and phenyl radicals as reactive intermediates. The latter also induce protein oxidation. These findings are associated with drug induced agranulocytosis. However, other biomolecular targets of these metabolites are...
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Spring 2016
Tamoxifen is the accepted therapy for patients with estrogen receptor α (ERα)−positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...