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Skip to Search Results- 1Brotto,Andrew R
- 1Collison, Breanne
- 1Cooper, Ian R
- 1Cox, Pendleton J M
- 1El-Sehemy, Ahmed Ali Ahmed Ali
- 1Forbes, Scott C
- 2Department of Physiology
- 2Faculty of Kinesiology, Sport, and Recreation
- 2Physical Education and Recreation
- 1Department of Biological Sciences
- 1Department of Oncology
- 1Faculty of Pharmacy and Pharmaceutical Sciences
- 1Bell, Gordon (Physical Education and Recreation)
- 1Carlos A Velázquez (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Davidge, Sandra (Obstetrics/Gynecology and Physiology)
- 1Davidge, Sandra (dept. of Physiology)
- 1DeLorey, Darren Faculty of Kinesiology, Sport, and Recreation
- 1DeLorey, Darren S (Physical Education and Recreation)
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Fall 2022
Contraction-mediated inhibition of sympathetic vasoconstriction (sympatholysis) is enhanced in female compared with male rats. Acute pharmacological blockade of nitric oxide (NO) production abolished the sex difference in sympatholysis, indicating that NO-mediated sympatholysis is elevated in...
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Spring 2022
Background: Carbon monoxide alters cardiovascular function through its actions as a signaling molecule and by limiting oxygen delivery in the blood, favouring pro-dilatory and anti-constrictor effects within the vasculature. The impacts of mild carbon monoxide exposure on vascular responses to...
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The Effect of Inhaled Nitric Oxide on Maximal Oxygen Consumption in High-fit and Untrained Individuals
DownloadFall 2019
Previous work suggests that endurance-trained athletes have superior pulmonary vasculature function as compared to untrained individuals, which may contribute to their greater maximal oxygen uptake (V̇O2max). Inhaled nitric oxide (iNO) improves pulmonary vascular compliance at rest in healthy...
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Are Sex and Estrogen Modulators of Sympathetic Vascular Control in Resting and Contracting Skeletal Muscle?
DownloadSpring 2018
The purpose of this thesis was to investigate whether sex and estrogen modulate sympathetic neurovascular control in resting and contracting skeletal muscle. This thesis also investigated the hypothesis that the effects of sex and estrogen on neurovascular control would be mediated by the signal...
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Spring 2017
Pulses of ecdysone, a steroid hormone, play an integral role during insect development however, how these ecdysone pulses are regulated has been relatively unexplored. I have shown that the presence of nitric oxide (NO) within the larval prothoracic gland (PG), the principal source of larval...
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Βeta-adrenergic receptors and opposition of evoked sympathetic vasoconstriction: Effects of sex and exercise training
DownloadFall 2016
Stimulation of the sympathetic nervous system evokes the release of neurotransmitters and produces vasoconstriction that is primarily mediated by the binding of norepinephrine (NE) to alpha-adrenergic receptors. However, NE may also bind to beta (β)-adrenergic receptors and produce vasodilation...
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Notch regulates the growth-promoting nitric oxide cGMP-dependent pathway in epithelial ovarian cancer and ovarian surface epithelium cells
DownloadSpring 2014
El-Sehemy, Ahmed Ali Ahmed Ali
Ovarian cancer is the leading cause of mortality among gynecologic cancers. There are several subtypes of ovarian cancer, amongst which epithelial ovarian cancer (EOC) makes up to 90% of all ovarian cancers. The current treatment for EOC consists of debulking surgery followed by a...
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Anesthesia and the Aging Vasculature: Effects of Propofol on Hemodynamics and Vascular Function
DownloadSpring 2014
An increasing life expectancy in Canada has resulted in increasing proportions of elderly patients requiring anesthetic care for surgical procedures. Aging is associated with cardiovascular changes resulting in increased vasoconstriction and hypertension, and medications such as angiotensin...
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NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health Authorities
DownloadSpring 2012
The objective of this work was to synthesize and evaluate the biological properties of a new series of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol linker between the carboxylic acid present in classical NSAIDs and a NO-releasing group (PROLI/NO)...
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Can L-arginine Influence the Acute Hormonal, Metabolic, and Physiological Responses at Rest and Prior to Exercise?
DownloadFall 2012
L-arginine is a conditionally essential amino acid and has recently been purported as ergogenic for both strength and aerobic athletes; however, the value of oral L-arginine supplementation in physically active participants is controversial. The purpose of this dissertation was threefold: first...