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Spring 2020
Activation of α5 GABAA receptors located on nodes of primary afferents have been found to produce a long lasting tonic primary afferent depolarization in the spinal cord (tonic PAD). In particular, C fibres have been found to be especially effective in eliciting this tonic PAD. Here by activating...
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Dynamic regulation of the cellular prion protein in microglia following histamine-induced stimulation
DownloadFall 2024
Although the cellular prion protein (PrPC) has been evolutionarily conserved throughout evolution, its precise role remains elusive. Recent findings suggest that PrPC may be involved in neuroinflammation and immune responses in the brain, and its expression can be modulated through various...
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Fall 2018
Physical training can affect the excitability of spinal reflexes in a training-specific manner in uninjured humans. Therefore, the first part of this thesis examined the changes in the excitability of a polysynaptic and a monosynaptic reflex in an ankle plantarflexor, after contrasting forms of...