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Insights into the Role of Phosphatidylethanolamine N-methyltransferase and the PC:PE Ratio in Liver Function
DownloadSpring 2019
PEMT is quantitatively important in the liver and is responsible for approximately 30% of hepatic PC synthesis, with the remaining 70% synthesized by the CDP-choline pathway. HFD-fed Pemt-/- mice and LPcyt1a-/- mice both develop NAFLD associated with reduced VLDL secretion and a reduced hepatic...
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Fall 2015
Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine (PC) biosynthesis via three sequential methylations of phosphatidylethanolamine (PE). PEMT is also expressed in white adipose tissue (WAT). When...