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A Comprehensive Dynamical Model for Human CaV1.2 Ion Channel: Structural and Functional Studies
DownloadFall 2019
Human CaV1.2 is a voltage-gated calcium channel (VGCC), which plays an essential role to maintain a normal cardiac function. Any abnormalities in CaV1.2 can lead to serious cardiac diseases (e.g. cardiac arrhythmias and Timothy syndrome). Thus, understanding the structure-function-dynamics...
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Spring 2019
Cancer remains a challenging disease to tackle. The heterogeneity and evolution of the disease necessitates the development of diverse approaches to treat cancer. In this thesis, two different approaches have been undertaken to address this issue. The first aim was to activate the master tumor...
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Localization Model description of interfacial dynamics of free-standing nanoparticles and thin films, and nanoparticle on supporting interacting substrate
DownloadFall 2022
Localization model (LM) relates, without any free parameter, slow dynamics of α-relaxation time (τα) to fast dynamics of Debye-Waller Factor (DWF) or ⟨u2⟩, which is the mean square displacement of particles at a caging time on the order of picoseconds. Moreover, localization model can also...
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Spring 2021
While PrP is almost always found in the glycosylated state, there has been very little study attempting to explore the effects of the size of glycans, the composition of glycans, and the site of glycosylation on the stability of PrP. These effects can potentially play an important role in the...