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Skip to Search Results- 2Al Sayah, Fatima
- 1Achtymichuk, Karly A
- 1Adame Perez, Stephany
- 1Al-Adra, David P.
- 1Albalawi, Zaina H
- 1Almukainzi, May Khalifah
- 8Department of Agricultural, Food, and Nutritional Science
- 6Department of Surgery
- 6School of Public Health
- 5Faculty of Pharmacy and Pharmaceutical Sciences
- 3School Public Health Sciences
- 2Department of Medical Microbiology and Immunology
- 2Eurich, Dean (School of Public Health)
- 2Johnson, Jeff A. (School of Public Health Sciences, University of Alberta)
- 2Williams, Beverly (Faculty of Nursing, University of Alberta)
- 1Al Hamarneh, Yazid (Pharmacology)
- 1Anderson, Colin (Medical Microbiology and Immunology and Surgery)
- 1Baldwin, Troy (Medical Microbiology and Immunology)
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Spring 2013
Glucose is the sole fuel for the brain in normal physiological conditions. Absence of glucose or its presence in high concentrations has been shown to be harmful to neurons. Microglia, the innate immune cells of the brain, are the first line of defense against changes in the CNS environment and...
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Cause of Death and the Impact of Implantable Cardioverter Defibrillators Among Patients with Diabetes Mellitus and Heart Failure
DownloadSpring 2020
Introduction: Diabetes and heart failure (HF) place a large burden on healthcare systems and are associated with increased risk for death, including sudden cardiac death (SCD). However, causes of death have not been fully explored and evidence for primary prevention...
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Exploring the Relationship Between Depression and Adherence in Individuals with Type 2 Diabetes
DownloadFall 2020
Background: Depression is a well-known risk factor for poor medication adherence in individuals with diabetes; however, this association is based on cross-sectional and cohort studies measuring adherence after depression is diagnosed. Symptoms of depression often progress before medical...
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The Effects of Elements of Cardiometabolic Syndrome on Metformin Disposition: Obesity and Hyperlipidemia
DownloadFall 2015
The influences of obesity, Roux-en-Y gastric bypass bariatric (RYGB) surgery and hyperlipidemia on metformin pharmacokinetics (PK) were investigated. A sensitive and novel HPLC-UV reverse phase assay method was developed and utilized. Detection and mass characterization for metformin metabolites...
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Drug Exposure Definition and Healthy User Bias Impacts on the Evaluation of Oral Anti Hyperglycemic Therapies
DownloadFall 2017
Accurate estimation of medication use is an essential component of any pharmacoepidemiological research as exposure misclassification will threaten study validity and lead to spurious associations. Many pharmacoepidemiological studies use simple definitions, such as the categorical “any versus no...
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Fall 2016
Relative to those without diabetes, individuals with type 2 diabetes have an increased risk of several cancers, but a decreased risk of prostate cancer. While metformin may reduce the risk of some cancers, it may not reduce the risk of prostate cancer. However, race/ethnicity may modify...
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Fall 2015
The development of the Edmonton protocol was an important milestone in the process of establishing islet transplantation as a cure for diabetes. However, many challenges must still be overcome, including the shortage of donor organs. To address this issue, we believe that neonatal porcine islets...
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The Effect of Metformin, Flutamide and Dietary Nicotinic Acid on Dyslipidemia and Cardiometabolic Risk in the JCR:LA-cp Rodent Model of PCOS
DownloadFall 2014
Polycystic ovary syndrome (PCOS) is a highly prevalent metabolic-endocrine disorder affecting up to 18% of adolescent and adult females in their reproductive years. PCOS is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes. Atherogenic dyslipidemia occurs in...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Assessment of food accessibility, availability and adherence to dietary recommendations among diabetic older adults living in subsidized retirement homes
DownloadSpring 2012
The availability and accessibility of healthy foods for type 2 diabetes patients may limit their food choices and adherence to dietary recommendations. The accessibility and availability of food for low-income, diabetic, older adults was evaluated. Information was gathered regarding self-care...