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Skip to Search Results- 5Department of Agricultural, Food, and Nutritional Science
- 3Department of Chemistry
- 2Department of Pharmacology
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Biochemistry
- 1Department of Chemical and Materials Engineering
- 2Proctor, Spencer (AFNS)
- 1Curtis, Jonathan (Agricultural, Food and Nutritional Science)
- 1Curtis, Jonathan (Department of Agricultural, Food and Nutritional Science)
- 1Dean Eurich (School of Public Health)
- 1Dr. Lucy, Charles A. (Chemistry)
- 1Dr. Michael Overduin (Department of Biochemistry)
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Fall 2011
Coupling supercritical CO2 extraction with membrane separation leads to energy savings by recycling CO2 at supercritical state while separating extract components. Commercially available polyamide-based membranes are commonly used with coupled systems due to their availability and robust...
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Development and Characterization of New Stationary Phases for Hydrophilic Interaction Liquid Chromatography
DownloadSpring 2014
Ibrahim, Mohammed Elsayed Abdelatif
Hydrophilic interaction liquid chromatography (HILIC) has gained high popularity among separation scientists in the last two decades due to its ability to retain polar analytes. Many new HILIC stationary phases with different selectivities have appeared in the recent literature. Such developments...
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Spring 2016
The analysis of thousands of metabolites and lipids for discovery of metabolite biomarkers for disease monitoring and diagnosis requires the highest sensitivity and robust methods. Metabolomics is the study of metabolites found in the body, which can be used to discover biomarkers of disease or...
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Extraction of Hydrocarbons from Bitumen and Bitumen-containing Process and Process Waste Streams using Supercritical Carbon Dioxide
DownloadSpring 2019
Extractions of hydrocarbons from bitumen and bitumen-containing process and process waste streams generated from surface mined oil sands were conducted using supercritical carbon dioxide (SC-CO2). Dynamic extractions were performed on a bench-scale batch supercritical fluid extraction (SFE)...
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Spring 2022
Background: In metabolic disease statues, such as diabetes and obesity, dyslipidemia is characterized by a dysregulation of lipid homeostasis, due in part to elevated triglyceride (TG)-rich very low-density lipoprotein (VLDL-TG) production and secretion by the liver. Further, these metabolic...
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In-line Ozonolysis coupled to Mass Spectrometry- A New Dimension of Structural Determination for Lipids
DownloadFall 2014
The location of double bonds within unsaturated lipids can greatly affect their biological functions. Liquid chromatography coupled to mass spectrometry (LC/MS) has become a powerful tool for lipid separation and structural elucidation. However, the determination of double bond position remains...
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J-Coupling Effects on Quantification of the 1.3 ppm Lipid Methylene Resonance with In-Vivo Magnetic Resonance Spectroscopy at 3 T
DownloadFall 2015
Quantification of 1.3 ppm lipid methylene protons by proton magnetic resonance spectroscopy has been shown to be relevant to a number of diseases. Additionally, T2 estimation of 1.3 ppm methylene protons has been used to grade the metastatic potential of colon tumours. J-coupling...
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Fall 2016
Lipidomics is a research field that attempts to achieve the comprehensive analysis of the entire lipidome in a biological system. The emergence and rapid expansion of lipidomic studies is driven by the great advances in chromatographic separation and mass spectrometry. For this dissertation, I...
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Spring 2013
Huntington disease (HD) is a neurodegenerative disorder characterized by motor and cognitive symptoms. In HD patients, the protein huntingtin contains an abnormal expansion of a polyglutamine tract, which leads to the selective dysfunction and death of striatal and cortical neurons. Among other...
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Spring 2015
Protein silencing by small interfering RNA (siRNA) is a promising treatment strategy for cancer as over-expression of proteins is largely responsible for cancer cells’ infinite proliferation, evasion of cell death and multi-drug resistance. However, siRNAs require a carrier as their biological...