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Skip to Search Results- 1Azad, Azar
- 1Csont, Tamas
- 1Dhami, Kamaldeep S
- 1Dyck, Jason R. B.
- 1Elezzabi, Muhammad A.
- 1Gros, Robert
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Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death
Download2002-01-01
Mungrue, Imran N., Gros, Robert, You, Xiaomang, Pirani, Asif, Azad, Azar, Csont, Tamas, Husain, Mansoor, Schulz, Richard
Increased inducible nitric oxide synthase (iNOS) expression is a component of the immune response and has been demonstrated in cardiomyocytes in septic shock, myocarditis, transplant rejection, ischemia, and dilated cardiomyopathy. To explore whether the consequences of such expression are...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Spring 2012
Stroke, a reduction in blood flow to the brain, activates various proteins that contribute to neuronal death. The matrix metalloproteinases (MMPs), specifically MMP2 and MMP9, are important in maintaining the blood brain barrier (BBB). After a stroke the BBB permeability increases which is...
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Influence of therapeutic hypothermia on neuroprotection and post-ischemic plasticity in a rat model of global ischemia
DownloadFall 2011
Blood flow to the brain may be disrupted by either a stroke (such as focal ischemia or hemorrhage) or cardiac arrest, where the whole brain becomes ischemic. Both forms of injury result in irreversible neuronal loss leading to neurological impairments and a decrease in the quality of life....
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Investigating Myocardial PI3Kα Signaling in Models of Ischemia Reperfusion and Cardiotoxic Cancer Therapies
DownloadSpring 2017
Background. Phosphoinositide 3-kinase (PI3K) is a lipid kinase that functions as a central intracellular signaling transduction node, receiving input from cell receptors and initiating a cascade of cellular signaling that regulates and integrates central cellular processes such as glucose uptake,...
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Long-term cardiovascular and metabolic effects of hypoxia-induced intrauterine growth restriction
DownloadSpring 2011
Rueda-Clausen, Christian Federico
Cardiovascular and metabolic diseases are still the primary cause of death and disability in modern society. Although genetic factors play a fundamental role in the development of these chronic conditions, the remarkable variability in an individual’s susceptibility to develop these pathologies...
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The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons
DownloadFall 2013
Depression is one of the most common disorders appearing following a stroke and is also a major factor limiting recovery and rehabilitation in stroke patients. Several antidepressants have shown to have anti-inflammatory properties within the central nervous system (CNS). The major source of...