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Skip to Search Results- 4Fliegel, Larry
- 1Alvarez, Bernando
- 1Casey, Joseph R.
- 1Dyck, Jason R. B.
- 1Gan, Xiaohong Tracey
- 1Karmazyn, Morris
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Activation of Na+/H+ exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium
Download2001-01-01
Moor, Andrea N., Gan, Xiaohong Tracey, Karmazyn, Morris, Fliegel, Larry
The activity of the Na+/H+ exchanger has been implicated as an important contributing factor in damage to the myocardium that occurs during ischemia and reperfusion. We examined regulation of the protein in ischemic and reperfused isolated hearts and isolated ventricular myocytes. In isolated...
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2002-01-01
Li, Xiuju J., Alvarez, Bernando, Casey, Joseph R., Reithmeier, Reinhart A. F., Fliegel, Larry
We examined the ability of carbonic anhydrase II to bind to and affect the transport efficiency of the NHE1 isoform of the mammalian Na+/H+ exchanger. The C-terminal region of NHE1 was expressed in Escherichia coli fused with an N-terminal glutathionineS-transferase or with a C-terminal...
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Regulation of Na+/H+ Exchanger Gene Expression: Role of a poly T rich region in regulation of expression of the NHE1 promoter
Download1996-01-01
Yang, Weidong, Wang, Huayan, Fliegel, Larry
In this study we examine regulation of expression of the Na+/H+ exchanger promoter in L6 and NIH 3T3 cells. We have identified a highly conserved poly(dA·dT)-rich region that appears to be important in regulation of expression of the NHE1 gene. Deletion or mutation of this region results in...
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Specific Activation of the Na+/H+ exchanger gene during neuronal differentiation of embryonal carcinoma cells
Download1995-01-01
Dyck, Jason R. B., Fliegel, Larry
We examined the regulation of the NaGraphic/HGraphic exchanger gene during differentiation of the P19 mouse embryonal carcinoma cells. Treatment of P19 cells with retinoic acid induces the development of neurons, astroglia, and microglia cells. Upon retinoic acid-induced differentiation of P19...