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An Exploration of the Associations Between Gut and Serum Immunoglobulin A in Infancy and Asthma in Childhood
DownloadSpring 2020
Introduction Early immune maturation and gut microbial composition have a clear impact on the development of asthma and atopy in children. There is a large body of evidence on the association between immunoglobulin A (IgA), asthma, and other atopic diseases. Low secretory Immunoglobulin A (sIgA)...
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Pre and postnatal maternal distress and infant gut immunity in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort
DownloadSpring 2017
Introduction: Secretory immunoglobulin A (sIgA) plays a critical role in gut mucosal immunity and is a marker of immune maturation in early life. Delayed IgA production is associated with increased risk of allergic diseases. Animal models of stressful events before birth and during infancy show...