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Skip to Search Results- 6Klassen, John S.
- 5Wishart, D.S.
- 4Kitova, Elena N.
- 3Fliegel, Larry
- 3Stothard, Paul
- 2Bagal, Dhanashri
- 26Graduate and Postdoctoral Studies (GPS), Faculty of
- 26Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 25Biological Sciences, Department of
- 24Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 8Chemistry, Department of
- 8Chemistry, Department of/Journal Articles (Chemistry)
- 5Department of Chemistry
- 5Department of Electrical and Computer Engineering
- 3Department of Agricultural, Food, and Nutritional Science
- 2Department of Chemical and Materials Engineering
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Biochemistry
- 2Huang, Biao (Chemical and Materials Engineering)
- 2Kurgan, Lukasz (Electrical and Computer Engineering)
- 1Adams, Catherine (Department of Secondary Education)
- 1Ball, Ronald O. (Department of Agricultural, Food and Nutritional Science)
- 1Ballermann, Barbara (Medicine)
- 1Boekhoven, Job (Chemistry, Technical University of Munich)
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Development and Application of Protected Amino Acids for the Installation of Stable Post-translational Modifications Using Solid-Phase Peptide Synthesis
DownloadFall 2022
This thesis describes the synthesis of non-canonical amino acid building blocks and their use in solid-phase peptide synthesis (SPPS) to explore peptidic drug analogues based on natural products. We replaced sensitive functionalities found in the structure of naturally produced peptides with...
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Sacred Space and Community Identities: Sanctuaries in Broader Thessaly from the Archaic to the Early Roman Periods
DownloadSpring 2021
This study examines the roles of sacred spaces in Thessaly as agents in the formation, maintenance, and negotiation of group identities in Thessaly from the Archaic period until the beginning of the Roman Imperial Period in Greece. I demonstrate that the individuals who formed the communities of...
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Multilocus species identification and fungal DNA barcoding: insights from blue stain fungal symbionts of the mountain pine beetle
Download2020-01-08
Roe, Amanda, Rice, Adrianne, Bromilow, Sean, Cooke, Janice, Sperling, Felix
There is strong community-wide interest in applying molecular techniques to fungal species delimitation and identification, but selection of a standardized region or regions of the genome has not been finalized. A single marker, the ribosomal DNA internal transcribed spacer region, has frequently...
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Interfacing Silicon-Based Quantum Dots with Proteins for Biological and Sensing Applications
DownloadFall 2020
This dissertation presents the preparation of functional bioinorganic hybrids from silicon-based quantum dots (SiQDs) and enzymes and the use of SiQDs and green fluorescent protein as ratiometric photoluminescent sensors for nerve agents. Chapter 2 discusses the preparation of water-soluble...
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Energy use by the mountain pine beetle (Coleoptera: Curculionidae: Scolytinae) for dispersal by flight
Download2019-01-01
Wijerathna, Asha, Evenden, Maya
The mountain pine beetle, Dendroctonus ponderosae Hopkins is a major native pest of pine (Pinus Linnaeus (Pinaceae)) in western North America. Host colonization by mountain pine beetle is associated with an obligatory dispersal phase, during which beetles fly in search of a suitable host....
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Probing microscopic conformational dynamics in folding reactions by measuring transition paths
Download2019-12-01
Hoffer, Noel Q, Woodside, Michael T
Transition paths comprise those parts of a folding trajectory where the molecule passes through the high-energy transition states separating folded and unfolded conformations. The transition states determine the folding kinetics and mechanism but are difficult to observe because of their brief...
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Spring 2018
The development of rapid and bioorthogonal chemical reactions has expanded greatly the utility of bioconjugation chemistry in the service of site-selective protein labeling, even allowing molecular imaging in live cells or animals. âClickâ chemistry is particularly desirable due to its fast...
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Fall 2018
Chloride intracellular channel (CLIC) proteins comprise six members CLIC1–CLIC6 in mammals and mediate functions not fully known. Their founding member was isolated from bovine kidney using the chloride channel inhibitor indanyloxyacetic acid-94, so CLICs were assumed to be typical anion...
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Spring 2018
Intrinsically disordered regions (IDRs) in proteins lack stable three dimensional structure under physiological conditions. IDRs are prevalent in nature, functionally important, and difficult to characterize experimentally due to their unstructuredness. As a result, many computational methods...