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- 1 Owttrim, George W.
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- 11Graduate and Postdoctoral Studies (GPS), Faculty of
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A large deletion virus reveals the presence of previously uncharacterized vaccinia virus inhibitors of NF-kB signaling
DownloadFall 2010
The classical Nuclear Factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immune responses. Poxviruses, including vaccinia virus, encode multiple immune evasion proteins, including a growing number of NF-κB inhibitors. To determine if additional vaccinia...
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Fall 2010
Mast cells are immune cells important in innate immunity. Besides their role in asthma and allergies, mast cells are critical effector cells against various pathogens. Mast cells are established to be protective against bacterial infections, but little is known about their functions in viral...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...
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Characterization of the cold stress-induced cyanobacterial DEAD-box protein CrhC as an RNA helicase
Download2000
Owttrim, George W., Yu, Esther
We have shown previously that CrhC is a unique member of the DEAD-box family of RNA helicases whose expression occurs specifically under conditions of cold stress. Here we show that recombinant His-tagged CrhC, purified from Escherichia coli, is an ATP-independent RNA binding protein possessing...
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Chart review of current end-of-life care needs and care practices in acute care hospitals: final report of an investigation
DownloadSpring 2011
A total of 1,018 charts of people who died from August 1, 2008 through July 31, 2009 were reviewed to describe and examine current end-of-life care needs and care practices provided in two acute care hospitals. The mean age of those who died was 72.5, the majority of decedents were elderly...
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Does the FamCHAT Tool Enhance the Ethno-Cultural Dimensions of Nursing Assessment at the Royal Alexandra Hospital (RAH)?
Download2011
Forgeron, J., Callender, S., Ortiz, L., Richter, S., Young, S., Boyce, M., Higginbottom, G.M.A
The RAH is located in one of Edmonton’s most ethnoculturally diverse neighbourhoods. Their interpretive service responds to >800 requests annually for > 30 languages. RAH staff requested identification and evaluation of a culturally-sensitive assessment tool suitable for enhancing nursing...
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Spring 2011
Medication safety is a key contribution to patient safety in health care settings. Health care researchers and scholars frequently report and discuss nurses’ medication administration practices or medication errors associated with patients’ safety in hospitals. Yet there are gaps in published...
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From Balkh to Baghdad: Indian science and the birth of the Islamic golden age in the eighth century
Download2016
The late first-century BCE caravan route from Antioch on the Mediterranean to Kandahar in modern Afghanistan provided opportunities for the exchange of medical knowledge between north India and the Parthian and Mediterranean worlds. Sanskrit literature provides evidence for the existence of...
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Incidence and prevalence of dementia in linked administrative health data in Saskatchewan, Canada: A retrospective cohort study
Download2015
Kosteniuk, Julie G., Crossley, Margaret, Teare, Gary F., Stewart, Norma J., Quail, Jacqueline M., Kirk, Andrew, Bello-Haas, Vanina Dal, O’Connell, Megan E., Forbes, Dorothy A., Morgan, Debra G., Innes, Anthea
Background Determining the epidemiology of dementia among the population as a whole in specific jurisdictions – including the long-term care population–is essential to providing appropriate care. The objectives of this study were to use linked administrative databases in the province of...
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Inhibition and enhancement of Respiratory Syncytial Virus replication by nucleoside analogues and bis(indole) compounds
DownloadSpring 2019
Respiratory syncytial virus (RSV) is an Orthopneumovirus that infects the epithelium of the airways. Severe RSV infection of the lower respiratory tract in infants is a leading cause of pediatric hospitalizations. RSV also causes substantial morbidity in immunocompromised and elderly populations....